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45 Cards in this Set
- Front
- Back
S100 antigen pos
neural crest/ ectoderm sm CC of lung carcinoid tumors melanoma neuroblastoma |
APUD tumors- neuroendocrine
|
|
MC sarcoma in kids
|
embryonal rhabdomyosarcoma
|
|
MC sarcoma in adults
|
malignant fibrous histiocytoma
then liposarcoma |
|
pleomorphic adenoma of salivary gland (parotid)
|
mixed tumor
|
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MC malignant lymphoma
|
non-hodgkins- B cell follicular lymphoma
|
|
synctiotrophoblasts secrete
|
bHCG
|
|
bronchial hamartoma
peutz-jeghers polyp hyperplastic polyp |
haratomas
|
|
30 doubling times
10^9 cells 1g tissue 1 ml volume |
clinically evident tumor
|
|
lymph node
|
usually a met from breast/lung cancer
primary= non hodgkins |
|
lung
|
usually a met from breast cancer
primary = adenocarcinoma |
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brain
|
usually a met from lung cancer
primary = gliobastoma multiforme in adults; medulloblastoma in kids |
|
liver
|
usually a met from lung
primary = hepatocellular carcinoma secondary to HBV |
|
bone
|
usually a met from breast cancer
primary = multiple myeloma; osteogenic sarcoma |
|
adrenal glands
|
usually a met from lung cancer
primary = adenocarcinoma |
|
most common cancer in lung and bones
|
breast cancer
|
|
MC cancer in liver and brain
|
lung cancer
|
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CD45
|
leukocyte malignancies
|
|
s100
|
neuroendocrine tumor
|
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s100 + CD45
|
malignant melanoma
|
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erb2-neu (HER2)
|
invasive ductal cancer- poor prognosis
|
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t(9;22)
|
philadelphia chromosome
bcr-abl fusion gene *CML |
|
ret point mutation
|
MEN syndromes
|
|
ras point mutations
|
30% of all human cancers
lung colon pancreas AML |
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t(8;14)
|
bcl2 overexpression
Burkitt's lymphoma EBV |
|
N-myc
|
neuroblastoma
|
|
Rb mutation
|
retinoblastoma
osteogenic sarcoma breast cancer |
|
p53 mutation
|
15-50% of all human cancers
colon brest lung CNS *Li-Fraumeni syndrome |
|
APC gene chr 5
|
adenomatous polyposis coli
*familial polyposis *Gardner's syndrome |
|
NF1 on chr 17
NF2 on chr 22 |
neurofibromatosis
|
|
BRCA-1
|
breast
ovarian colon prostate |
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transitional carcinoma of bladder
|
cigarette smoke
cyclophosphamide |
|
angiosarcoma of lvier
|
vinyl chloride
|
|
lung cancer
|
cigarette smoke
|
|
hepatocellular carcinoma
|
aflatoxins; esp with HBV
|
|
leukemia
|
benzene
|
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SqCC of oral pharynx
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cigarette smoke
|
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SqCC of esophagus
|
cigarette smoke
alcohol |
|
MC paraneoplastic syndrome
|
hypercalcemia (usually from mets to bone, or from PTHrP)
|
|
eaton lambert
|
MG paraneoplastic syndrome assoc with SmCC of lung
|
|
Leser-Trelat sign
canthosis nigricans |
gastric adenocarcinoma
|
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Trausseau's
|
pancreatic adenocarcinoma
|
|
MEN I
|
pituitary
parathyroid pancreatic |
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MEN II
|
medullary thryoid
parathyroid pheochromocytoma |
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MEN III
|
medullary thrygoid
mucosal neuromas pheochromocytoma |
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von Hippel Lindau
|
cerebellar hemangioblastoma
bilateral renal adenocarcinoma pheochromocytoma |