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45 Cards in this Set

  • Front
  • Back
S100 antigen pos
neural crest/ ectoderm
sm CC of lung
carcinoid tumors
melanoma
neuroblastoma
APUD tumors- neuroendocrine
MC sarcoma in kids
embryonal rhabdomyosarcoma
MC sarcoma in adults
malignant fibrous histiocytoma
then liposarcoma
pleomorphic adenoma of salivary gland (parotid)
mixed tumor
MC malignant lymphoma
non-hodgkins- B cell follicular lymphoma
synctiotrophoblasts secrete
bHCG
bronchial hamartoma
peutz-jeghers polyp
hyperplastic polyp
haratomas
30 doubling times
10^9 cells
1g tissue
1 ml volume
clinically evident tumor
lymph node
usually a met from breast/lung cancer
primary= non hodgkins
lung
usually a met from breast cancer
primary = adenocarcinoma
brain
usually a met from lung cancer
primary = gliobastoma multiforme in adults;
medulloblastoma in kids
liver
usually a met from lung
primary = hepatocellular carcinoma secondary to HBV
bone
usually a met from breast cancer
primary = multiple myeloma; osteogenic sarcoma
adrenal glands
usually a met from lung cancer
primary = adenocarcinoma
most common cancer in lung and bones
breast cancer
MC cancer in liver and brain
lung cancer
CD45
leukocyte malignancies
s100
neuroendocrine tumor
s100 + CD45
malignant melanoma
erb2-neu (HER2)
invasive ductal cancer- poor prognosis
t(9;22)
philadelphia chromosome
bcr-abl fusion gene

*CML
ret point mutation
MEN syndromes
ras point mutations
30% of all human cancers
lung
colon
pancreas
AML
t(8;14)
bcl2 overexpression
Burkitt's lymphoma
EBV
N-myc
neuroblastoma
Rb mutation
retinoblastoma
osteogenic sarcoma
breast cancer
p53 mutation
15-50% of all human cancers
colon
brest
lung
CNS

*Li-Fraumeni syndrome
APC gene chr 5
adenomatous polyposis coli

*familial polyposis
*Gardner's syndrome
NF1 on chr 17
NF2 on chr 22
neurofibromatosis
BRCA-1
breast
ovarian
colon
prostate
transitional carcinoma of bladder
cigarette smoke
cyclophosphamide
angiosarcoma of lvier
vinyl chloride
lung cancer
cigarette smoke
hepatocellular carcinoma
aflatoxins; esp with HBV
leukemia
benzene
SqCC of oral pharynx
cigarette smoke
SqCC of esophagus
cigarette smoke
alcohol
MC paraneoplastic syndrome
hypercalcemia (usually from mets to bone, or from PTHrP)
eaton lambert
MG paraneoplastic syndrome assoc with SmCC of lung
Leser-Trelat sign
canthosis nigricans
gastric adenocarcinoma
Trausseau's
pancreatic adenocarcinoma
MEN I
pituitary
parathyroid
pancreatic
MEN II
medullary thryoid
parathyroid
pheochromocytoma
MEN III
medullary thrygoid
mucosal neuromas
pheochromocytoma
von Hippel Lindau
cerebellar hemangioblastoma
bilateral renal adenocarcinoma
pheochromocytoma