Pathology Male Gu Morph Descriptions

Front 1

- hyalnized thickening of the seminiferous tubules' basement membranes
-grossly small fibrotic pale white testes

Back 1

cryptorchidism
- leydig cells appear more prominant
- Leydig cells functions normally, but spermatogenesis stops. (sertoli cells via FSH spermatogenesis; leydig testosterone via LH)

Front 2

1. soft gray-white plaque w/ ulceration on penis
2. single/multiple velvety red plaques
3. multiple red/brown papules

Back 2

carcinomas in situ

1. Bowen disease
2. Erythroplasia of Queyrat
3. Bowenoid papulosis (HPV 16)

Front 3

Sheets of uniform cells divided in LOBULES by fibrous tissue septa.
-all cells look like spermatogonia (primative germ cells)
-placental alkaline phosphatase +
- keratin +

"homogenous, gray-white lobulated lesion, histo w/ polyhedral clear cells w/ central nuclei, embedded in lymphoid stroma"

Back 3

seminoma

grossly: no hemorrage or necrosis

Front 4

all cells look like spermatogonia
-PLAP immunohisochemistry

Back 4

intratubular germ cell neoplasia. germ cell tumors arise from this

Front 5

Tumor w/ three cell populations
Spermatogonia-like cells
Smaller secondary spermatocyte-like cells
Scattered giant cells

Back 5

Spermatocytic seminoma
(not ITGC derived, doesn't metastasize so :) prog)

Front 6

tumor
- Cells grow in cords and sheets; no well formed
glands
- Epithelial appearance
- Large hyperchromatic cells with variable anaplasia and indistinct cell borders
- Scattered syncytial giant cells which elaborate HCG (human chorionic gonadotrophin) and/or AFP (alpha fetoprotein)

Back 6

Embryonal Carcinoma

+ hemorrhage/necrosis
aggrssive

Front 7

tumor
- Lace-like network of medium sized cuboidal cells, papillary structures and solid cords
- Schiller-Duval
bodies (mesodermal core with
adjacent cells resembling primitive glomeruli)

"sheets of cells and ill-defined glands made of cuboidal cells some of which contain eosinophilichyaline globules; glomeruloid structures"

Back 7

Yolk Sac Tumor
-alpha feto protein

Front 8

tumor composed of cytotrophoblasts (polygonal w/ distinct borders) and syncytiotrophoblasts (large eosinophilic cells w/ hyperchromatic lobular nuclei)

"cuboidal cells intermingled with large eosinophilic synctial cells containing multiple, dar, pleomorphic nuclei; extensive necrosis/hemorrhage"

Back 8

Choriocarcinoma
- hCG elevation
-bloodstream metastases rather than usual lymphatic
-REALLY BLOODY

Front 9

crystalloids of Reinke in cytoplasm

Back 9

in 25% of Leydig Cell tumors (benign)

Front 10

high PSA + nothing palpable on rectal exam. glands packed back to back, with single layer of epithelium lining

Back 10

adenocarcinoma (most common prostate carcinoma.
- most don't produce obstruction/not palpable on rectal exam
- NORMAL HYPERPLASTIC GLANDS HAVE DOUBLE LAYER EPITHELIAL LINING

-carcinoma raises PSA much MUCH more than hyperplasia or prostatis

Front 11

patchy loss of seminiferous tubules

Back 11

inflammation induced damage (mumps, gonorrhea can cause orchitis), versus widespread atrophy by klinefelter's, or female hormone therapy.

note: kids w/ mumps usually don't get orchitis

Front 12

solid and cystic tubules and cords of flat to cuboidal VACUOLATED cells and HYALINIZED stroma

Back 12

adenomatoid tumor (painless scrotal mass)

Front 13

neoplasia on glans of penis. well differentiated w/ pushing borders. locally invasive but no metastases. looks papillary grossly

Back 13

verrucous carcinoma (different from condylomata acuminata which also has papillary appearance (HPV) in that this CAN invade underlying tissus)