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31 Cards in this Set
- Front
- Back
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Type I fibres are:
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Oxidative
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Type IIb fibres are:
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glycolytic
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What are the satelittle cells called?
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Myoblasts
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What are some of the ways a muscle can respond to injury?
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HYpertrophy
Atrophy Degen and necrosis |
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Sucessful regen requires
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intact basal lamina
Viable satelittle cells |
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You find a large, deeply stained fibre with rounded borders, what does it suggest?
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Segmental necrosis
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What happens following segmental necrosis?
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Myofibre fragments, giving vaculoated appearance
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What will clean up the debris?
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Macrophages
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What wil disapear during regeneration?
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Plasmalemma
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Whta happens to satelittle cells during regen?
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Move to centre, become myoblasts
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What line uo end to end and form myotubules?
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Myoblasts!
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What color are the myotubukes?
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dark blue, basophillic due to high RNA
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In myofibres where are the nuclei>
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Periphery
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If the basal lamina in not intact or the satelittle cells are not viable, how does it heal?
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Fibrosis
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How do we classify lesions in mm?
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Spatial distribution and temporal distribution
focal + multi focal + generalised Monophasic Polyphasic |
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Give some examples of multifocal polyphasic
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Repeat toxins,
nutrional, Genetic, stress related |
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List the common congential muscular disorders
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Hyerplasia - double muscling
Dystrophy Myotonia Malignant hyperthermia Porcine stress syndrome |
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What gene causes double muscling?
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Myostatin gene defect.
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What geme causes x linked muscular dystrophyu?
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Dystrophin gene
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How are muscles affected by the dystrophin gene defect?
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repeated bouts of regen/necrosis
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How would you classify x-linked muscular dystrophy?
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multifocal, polyphasic
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How quickly will severely affected young pups die?
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few days
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What breeds are affected by x linked muscular dystrophy?
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retrievers + terriers + rotties
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Describe the affect of myotonia
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Inability for muscle to relax following contraction
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What is myotonia
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inability for muscle to relax following stimulation.
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What kind of defect causes myotonia?
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Na Cl ion channel defect
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How does myotonia present?
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Stiff gait, muscle spasms.
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Describe malignant hyperthermia
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unregulated release of calcium from sarcoplasmic reticulum, leads to severe, prolonged contraction - hyperthemia
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What triggers and MH attack?
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related to stress
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What mutation causes porcine stress syndrome?
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HAL 1843
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What does PSE stand for?
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pale soft exudative.
(also includes rapid rigorM, other argans affected by rapid heart failure) |
