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27 Cards in this Set
- Front
- Back
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What is the neoplasm associated with Down's syndrome?
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ALL, AML (we ALL fall down)
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What is the neoplasm associated with xeroderma pigmentosum, albinism?
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melanoma, basal cell carcinoma and especially squamous cell carcinoma of the skin
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Gastric adenocarcinoma is associated with what conditions?
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Chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants
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What neoplasms are associated with tuberous sclerosis (facial angiofibroma, seizures, mental retardation)?
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astrocytoma, angiomyolipoma, cardiac rhabdomyoma
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What neoplasm is associated with actinic keratosis?
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squamous cell carcinoma of the skin
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What neoplasm is associated with barrett's esophagus (chronic GI reflux)?
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Esophageal adenocarcinoma
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What neoplasm is associated with Plummer- Vinson syndrome (esophageal web, atrophic glossitis, anemia: all from iron deficiency)
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squamous cell carcinoma of the esophgus
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What neoplasm is associated with cirrhosis (alcoholic, hep B and C)?
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hepatocellular carcinoma
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What neoplasm is associated with UC?
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colonic adenocarcinoma
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What neoplasm is associated with Paget's disease of bone?
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secondary osteosarcoma and fibrosarcoma
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What neoplasm is associated with immunodeficiency states?
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malignant lymphoma
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What neoplasm is associated with AIDS?
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aggressive malignant lymphomas (non-hodgkin's) and kaposi's sarcoma
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What neoplasm is associated with autoimmune diseases (Hasimotos thyroiditis, myasthenia gravis)?
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lymphoma
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What neoplasm is associated with Acanthosis nigricans (hyperpigmentation and epidermal thickening)?
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visceral malignancy (stomach, lung, breast, uterus)
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What neoplasm is associated with a dysplastic nevus?
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malignant melanoma
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What neoplasm is associated with radiation exposure?
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sarcoma, and papillary cancer of the thyroid
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oncogenes
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gain of function - cancer
*Need to damage only 1 allele survival message! |
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abl
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oncogene in CML (bcr-abl) 9:22 (philadelphia chromosome)
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c-myc
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oncogene in burkitt's lymphoma (non-hodgkins lymphoma
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bcl-2
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oncogene in follicular and undifferentiated lymphomas (inhibits apoptosis)
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erb-B2
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oncogene in breast, ovarian, and gastric carcinomas
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ras
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oncogene in Colon carcinoma
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L-myc
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oncogene in lung tumor
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N-myc
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oncogene in neuroblastoma
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ret
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oncogene in MEN types II and III
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c-kit
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oncogene in gastrointestinal stromal tumor (GIST)
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tumor suppressor gene
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loss of function - cancer: both alleles must be lost for expression of disease
*these genes normally turn of cell proliferation - if you loose these get uncontrollable cell growth |
