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18 Cards in this Set
- Front
- Back
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Male vs female prevalance of SLE
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Female:Male = 9:1
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Geographic and racial distribution of SLE
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More common in urban areas.
Higher among, Blacks, Asians, Hispanics |
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Age at onset of SLE
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65% b/t 16 and 55
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4 Genetic markers more frequent w. SLE
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HLA-B8, HLA-DR2, HLA-DR3, DQW1
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Hormones and SLE
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Estrogen upregulates immune system, androgens suppress
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Antibodies w/ high coralation w/ SLE
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Anti ds DNA , Anti-Smith (core proteins of SNRPs)
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Environmental factors related to SLE
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Mycobacterial infection-->anti-DNA antibodies?
anti-EBV titers higher in SLE patients Sunlight? stimulates b cells to make antibodies |
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Criteria for Classification of SLE
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4 of the following 11 criteria
1. Malar rash 2. Discoid rash. 3. Photosensitivity 4. Oral Ulcers 5. Arthritis 6. Serositis (pleuritis or pericarditis) 7. Renal disorder 8. Neurologic disorder (seizures or psychosis) 9. Hematologic disorder (Hemolytic anemia w/ reticulocytosis, or Leukopenia, lymphopenia, or thrombocytopenia) 10. Immunologic disorder (Anti-ds, anti-Sm, and/or antiphospholipid) 11. Antinuclear antibody |
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SLE kidney damage mechanism
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immune complex deposition in renal structures
may include a thrombotic process in glomerular capiries due to antiphospolipid |
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two types of antibodies in SLE antiphospholipid antibody syndrome
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Lupus anticoagulant, directed against plasma proteins (prothrombin or anexin V. Longer PTT (intrinsic), increased thrombosis
Anticardiolipin antibodies: against phospholipids, can give false positive for syphilis test |
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SLE prognosis
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80% 10 year survival.
subset w/ renal disease, hypocomplementemia, hypoalbuminemia mortality over 70% at 20 yrs |
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characteristic antibody of Drug induced LE
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anti-histone
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hyperplastic projections of synovial tissue over articular cartilage in RA, why a problem?
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pannus formation, cuts off O2 flow, faciliatates protease flow
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RA pathogenesis
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plasma cells in synovium produce IgM and IgG antibodies to Fc of IgG "rheumatoid factors"
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antibody associated with systemic sclerosis--diffuse
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Anti-DNA topoisomerase I
(Scl-70) |
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Antibody correlated with Limited Scleroderma--CREST
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anti-centromere
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Sjorgen Syndrome antibodies
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Anti--RNPs: SS-A (Ro), SS-B (La)
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Inflammatory Myopathies correlated antibody
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Anti-Histidyl-t-RNA synthetase (Jo-1)
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