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18 Cards in this Set

  • Front
  • Back
Male vs female prevalance of SLE
Female:Male = 9:1
Geographic and racial distribution of SLE
More common in urban areas.
Higher among, Blacks, Asians, Hispanics
Age at onset of SLE
65% b/t 16 and 55
4 Genetic markers more frequent w. SLE
Hormones and SLE
Estrogen upregulates immune system, androgens suppress
Antibodies w/ high coralation w/ SLE
Anti ds DNA , Anti-Smith (core proteins of SNRPs)
Environmental factors related to SLE
Mycobacterial infection-->anti-DNA antibodies?
anti-EBV titers higher in SLE patients
Sunlight? stimulates b cells to make antibodies
Criteria for Classification of SLE
4 of the following 11 criteria
1. Malar rash
2. Discoid rash.
3. Photosensitivity
4. Oral Ulcers
5. Arthritis
6. Serositis (pleuritis or pericarditis)
7. Renal disorder
8. Neurologic disorder (seizures or psychosis)
9. Hematologic disorder (Hemolytic anemia w/ reticulocytosis, or Leukopenia, lymphopenia, or thrombocytopenia)
10. Immunologic disorder (Anti-ds, anti-Sm, and/or antiphospholipid)
11. Antinuclear antibody
SLE kidney damage mechanism
immune complex deposition in renal structures
may include a thrombotic process in glomerular capiries due to antiphospolipid
two types of antibodies in SLE antiphospholipid antibody syndrome
Lupus anticoagulant, directed against plasma proteins (prothrombin or anexin V. Longer PTT (intrinsic), increased thrombosis

Anticardiolipin antibodies: against phospholipids, can give false positive for syphilis test
SLE prognosis
80% 10 year survival.
subset w/ renal disease, hypocomplementemia, hypoalbuminemia mortality over 70% at 20 yrs
characteristic antibody of Drug induced LE
hyperplastic projections of synovial tissue over articular cartilage in RA, why a problem?
pannus formation, cuts off O2 flow, faciliatates protease flow
RA pathogenesis
plasma cells in synovium produce IgM and IgG antibodies to Fc of IgG "rheumatoid factors"
antibody associated with systemic sclerosis--diffuse
Anti-DNA topoisomerase I
Antibody correlated with Limited Scleroderma--CREST
Sjorgen Syndrome antibodies
Anti--RNPs: SS-A (Ro), SS-B (La)
Inflammatory Myopathies correlated antibody
Anti-Histidyl-t-RNA synthetase (Jo-1)