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42 Cards in this Set

  • Front
  • Back
condyloma accuminata
wartlike lesions, vulva, vagina, cervix.

assoc. w/ HPV 6, 11.

Mic: Koilocytosis: vacuolization around nucleus, acanthosis, hyperkeratosis, parakeratosis
Papillary hidradenoma
benign tumor, along milk line, histo similar to intraductal papilloma.
Extramammary Paget Dz of vulva
usually labia majora

Micro: intraepidermal malignant cell with pagetoid cells
Vaginal adenosis and clear cell carcinoma of vagina
Rare, assoc w/ DES exposure in utero
Sarcoma botryoides (embryonal rhabdomyosarcoma (vagina)
infants and children
gross: poypoid, "grape like" soft tissue protruding from vagina

Micro: cells with cross-striations (strap cells).

grow underneath vaginal epithelium.

POS for "desmin" marker!
PID (cervix)
ascending infection, usually STD (gonorrhea and/or chlamydia).

Endometritis, salpingitis, pelvic abscess
Fitz-Hugh-Curtis Syndrome
aka perihepatitis, characterized by violin-string adhesion between fallopian tube and the liver capsule SEEN IN PID.
Complications of PID
tubo-ovarian abscess, tubal scarring resulting in infertility and ectopic tubal preg. Also intestinal obstruction
Icidence of Cancer
Endometrial > Ovarian > Cervical
Ovarian > endometrial > cervical

Cervical number one in the world.
Cervical carcinoma
Risky behavior (sex) of contracting HPV, smoking, STD's, immunosupression.

Peaks in the 40's.
High risk ones are Type 16, 18, 31, 33, 45.

E6 binds p53
E7 binds Rb
Progression of Cervical Squamous cell carcinoma
CIN (cervical Interaepithelia Neopplasia): CIN I (mild dysplasia), CIN II: moderate, CIN III Severe, CIS (in situ) and then invasion of basement membrane.
Cervical Cancer: Clinical presentation
Postcoital (after sexual untion) vaginal bleeding, pain during intercourse (dyspareunia), malodorous discharge, or asymptomatic.
Chronic: PLASMA cell in endometrium (should not be normally there). Assoc w/ PID, IUDs etc.

Acute: ascending infection from cervix, preg, abortion.
presence of endometial stroma and glands outside the uterus. commonly in ovary, pouch of douglas behind uterus,.

Gross: ovarian "CHOCOLATE" cyst.

red brown serosal nodules: "poweder burn".
Endometriosis: clinical presentation
chronic pelvic pain, dysmenorrhea, dyspareunia, infertility, rectal pain, constipation.
Leiomyoma (fibroids)
most common tumor of genital tract in females.

Huge in African Americans. responsive to Estrogen.

"rubbery white tan appearance, well circumcised, multiple".

"Whorl-like trabeculated appearance on cut section."

may goto Leiomyosarcoma
Endometrial carcinoma
Most common malignant tumor. common in POST-MENOPAUSAL females.

risk factors: nulliparity, obesity, estrogen RT, tamoxifen, E2 producing ovarian tumors (granulosa cell tumors).//
Lynch Syndrome
colon, endometrial and Ovarian cancers.
Endometrial carcinoma: gross and CP
Clin Presentation: Post-menopausal bleeding.

Gross: polypoid, TAN

Most common type: Endometriod adenocarcinoma
Polycystic Ovarian Dz
aka Stein-Leventhal Syndrome

benign, bilateral, follicular cysts.

young female, oligo, amenorrhea, hirsuitism, infertility, obesity.

Lab: high LH, Low FSH, High Testosterone

Tx: with BC or Provera
Epithelial Ovarian Tumors
Most common form of Ovarian tumor.

1. Cystadenoma: benign, unilocular, simply serous or mucous. can be MASSIVE

2. borderline tumors: low malignant potential

3. Cystadenocarcinoma: most common malignant ovarian tumor.
complex multioculated cysts, nodular and solid areas.

Micro: papillary structures with PSAMOMMA BODIES, stromal invasion.

Spread via seeding peritoneal cavity.
Heridatary risk factors: cystadenocarcinoma of ovary
BRCA-1, Lynch Syndrome

Marker: **CA 125**.

Presenation: vague, late presenation
Ovarian Germ cell tumors
Teratoma, Dysgerminoma, Yolk sac tumor, choriocarcinoma
Teratoma of ovary
aka dermoid cysts. Have all three germ cell components, mostly benign, common in younger women.

May have hair, teeth, bone, cartillage etc.
Struma Ovarii
preponderonce of thyroid tissue in teratoma, causes hyperthyroidism
immature teratoma
some elements are immature and is troublesome because it can become malignant via transformation.
Complications: teratoma
torsion, rupture, malignant tranformation (1%) usually SCC.
female equivalent of seminomas.//

young adults, radiosensitive.

High risk in: Turner syndrome, pseudohermaphrodites.//
Ovarian Sex-cord stromal tumors
ovarian fibroma, granulosa cell tumor, sertoli-leydig cell tumor (androblastoma)
Ovarian fibroma
firm, WHITE masses, most common stromal tumor

may present as Meigs syndrome
Meig syndrome
fibroma + ascites + pleural effusion (right-sided)
Granulosa cell tumor
potentially malignant, CAN PRODUCE ESTROGEN.

precocious puberty, irregular cycles,

Postmenopausal; bleeding again.

Gross: YELLOW white mass.

Micro: polygonal tumor cells, follicle like structure (CALL-EXNER BODIES)

complication: endometrial hyperplasia, and cancer.
sertoli-leydig cell
ANDROGEN producing., risk of pseudohermaphrodite offspring, virilization
Metastatic tumors of ovary
KRUKENBERG tumor: a metastatic carcinoma of the ovary, usually bilateral and secondary to a mucous carcinoma of the stomach, which contains signet-ring cells filled with mucus.breast, colon, endometrial.
Gestational Trophoblastic Disease
Hydatidiform mole (molar pregnancy), invasive moles, choriocarcinoma.
Hydatidiform Mole (molar pregnancy)
tumor of trophoblastic (placental) tissue.

Result from fertilization of an ovum that has lost all of its chromosomes.

at extremes of reproductive life, higher in Asia than US

CC: Size greater than dates (uterus), vaginal bleeding, passage of grapelike soft tissue

Micro: edematous chorionic villi, trophoblast proliferation, fetal tissue (in partial mole)

Tx; curettage, follow with beta hCG levels.

about 1 in 1000 pregnancies.
Complete Mole
diploid, 46 all paternal chromosomes, elevated hCG, NO fetal tissue, 2% to choriocarcinoma.
Partial Mole
69 chromosomes (23X maternal, 23X one sperm, 23Y the other sperm) XXY (triploid cells)

somewhat elecated hCG, fetal tissue present, rarely goes to choriocarcinoma.
most malignant tumor in humans, derived from trophoblast

Responsive to chemotherapy

Hematogenous spread to lungs, brain and liver etc.