Pathology: Hematopathology: Plasma Cell Neoplasms, Block I

Front 1

These B cell proliferations contain neoplastic plasma cells that almost always secrete a monoclonal Ig or Ig fragment:

Back 1

Plasma Cell Neoplasms

Front 2

______ _____ _____ often synthesize excess heavy or light chains along with complete Igs.

Back 2

Plasma cell neoplasms

Front 3

These disease create extra light chains that are able to be secreted in the urine and are known as Bence-Jones proteins.

Back 3

Plasma Cell Neoplasms

Front 4

This is a B cell neoplasm that usually presents in the 6th or 7th decade of life and commonly secretes monoclonal IgM, often in amounts sufficient to cause hyperviscosity syndrome;

Back 4

Lymphoplasmacytic Lymphoma

Front 5

Lymphoma of B cells undergoing terminal differentiation to plasma cells, most commonly secreting IgM immunoglobulin

Back 5

Lymphoplasmacytic Lymphoma

Front 6

This disease usually presents in 60 and 70 year olds, is incurable, progressive, and has symptoms that include; visual problems (retinal vein congestion), headaches, dizziness, deafness, bleeding, and cryoglobulinemia (precipitation of IgM at low temps)

Back 6

Lymphoplasmacytic Lymphoma

Front 7

This plasma cell neoplasm is characterized by mutifocal involvement of the skeleton.

Back 7

Multiple Myeloma

Front 8

This disease presents usually around 65 or 70 years old, Ig genes show evidence of somatic hypermutation, and neoplastic plasma cells mediate bone destruction:

Back 8

Multiple Myeloma

Front 9

The proliferation and survival of myeloma cells are dependent on several cytokines, most notably ______.

Back 9

IL-6

Front 10

Destructive plasma cell tumors involving the axial skeleton:

Back 10

Multiple Myeloma

Front 11

In this disease the marrow contains and increased number of plasma cells (>30%), with bizarre, multinucleated cells, and rouleaux formation:

Back 11

Multiple Myeloma

Front 12

This disease is associated with pathologic fractures and commonly death is caused by renal insufficiency due to Bence-Jones proteins:

Back 12

Multiple Myeloma

Front 13

Neoplastic proliferation of mature plasma cells, usually producing IgG or IgA or fragment

Back 13

Multiple Myeloma

Front 14

In this disease tumor cells upregulate RANKL to activate osteoclasts, breakdown causes hypercalcemia and urinary stones

Back 14

Multiple Myeloma

Front 15

What is the triad of Multiple Myeloma?

Back 15

1. Monoclonal protein in electrophoresis
2. Plasmacytosis of bone marrow
3. Lytic bone lesions

Front 16

What are some treatments for Multiple Myeloma?

Back 16

Bone marrow transplant, chemotherapy, and thalidamide (anti-angiogenesis)

Front 17

Plasma cell neoplasm presenting as a solitary lesion of bone or soft tissue:

Back 17

Solitary Myeloma (Plasmacytoma)

Front 18

Bone lesions in this disease progress to Multiple Myeloma - see a modest elevation in monoclonal proteins in some patients:

Back 18

Solitary Myeloma

Front 19

Most common plasma cell neoplasm, considered to be early MM, small amounts of monoclonal protein but no signs or symptoms of MM

Back 19

Monoclonal Gammopathy of Undetermined Significance