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35 Cards in this Set
- Front
- Back
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What are three outcomes of injury?
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Resolution, Regeneration, & Repair
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Will normal function be returned to a system after repair?
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No. Scar tissue will form.
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Give an example of a labile cell:
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Epithelial cell
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Provide an example of a stable cell:
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Hepatocyte
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Name two examples of quiescent cells:
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Myocardium, neuron, etc.
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Give two functions of the stroma:
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1. Mechanical scaffold for organ, 2. Provides nutrients to the parenchyma
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Regeneration is dependent on 3 things:
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1. Cell type, 2. Condition of the Stroma, 3. Number of cells present.
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How much of the liver can you lose and still regenerate it?
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Up to 2/3 loss.
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What is one stromal effect of type 1 diabetes?
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Filling of Islets in the pancreas with stroma.
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What's one problem which could affect regeneration in the liver?
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Dense stromal accumulations forming nodules from Cirrhosis
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Will you get regeneration or repair in the case of a burst Abscess?
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Repair.
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What's the defining characteristic of a Primary Union?
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Sterile, clean cut.
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State 5 steps of healing/repair:
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1. Hemostasis, 2. Acute Mild Inflammation, 3. Granulaiton, 4. Epithelialization, 5. Cicatrization
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What does fibrin polymerization create?
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A clot, and a scaffold for healing/repair.
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What does VEGF cause?
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Vascular endothelial growth factor will cause angiogenesis
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What is bFGF?
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Basic fibroblast growth factor will be chemotactic to fibroblasts.
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Describe granulation tissue:
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Neovascularization & wetness
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Give the steps of angiogenesis (5):
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1. Proteolysis of ECM, 2. Migration/Chemotaxis, 3. Proliferation, 4. Lumen formation/inhibition of growth, 5. Increased permeability
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What stops epithelialization from occuring all the time?
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Contact inhibition
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What type of collagen is irregularly arranged?
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Type III
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What type of collagen is arranged regularly during healing?
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Type I
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What's the defining characteristic of a Secondary Union?
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Non-sterile, likely infected gaping wound.
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Rattle off up to 8 things which will slow wound healing:
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Infection, large wound, re-wounding, Vascular disease, CT disorder, malnutrition, smoking ,steroids, etc.
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Steroids increase the activity of what enzyme?
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Collaginase
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Which vitamin will help patients on steroids heal?
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Vitamin A.
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Name two types of aberration to healing:
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1. Exuberant Granulation, 2. Proliferation of Scar Tissue
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What's an ocular manifestation of exuberant granulation?
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Pyogenic granuloma
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What are two manifestations of scar tissue proliferation?
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Keloid and Cicatricial entropion
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What two phases of healing/repair occur almost simultaneously?
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Inflammation & Hemostasis
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What does PVR stand for?
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Proliferative Vitreoretinopathy.
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"Star poles" are observed in:
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PVR (Proliferative Vitreoretinopathy).
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What do you call excess fluid in the abdomen?
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Ascites [belly]
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Histological analysis shows an accumulation of monocytes surrounding hepatocytes. What sort of inflammation is this?
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Chronic Inflammation
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An enlarged grainy hepatocyte. What sort of degeneration could cause this?
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Hydropic degeneration.
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Elevated PMNs: Chronic or Acute Inflammation?
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Acute.
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