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30 Cards in this Set
- Front
- Back
What is the most common disaccharide deficiency leading to malabsorption?
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lactase => milk intolerance
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Fundal gastritis (type A) is characterized by 4 A's, what are they?
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Autoimmune disorder with Autoantibodies to parietal cells, pernicious Anemia, Achlorydia
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Antral gastritis (Type B) is caused by:
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a Bug, H. Pylori infection
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Both forms of gastritis carry an increased risk of what?
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Gastric carinoma
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2 etiologic agents underlying gastric ulcers are:
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H. pylori (70%) and NSAID's
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Degeneration of what leads to gastric ulcers?
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Gastric mucosal protection v. gastric acid
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Does the pain of a gastric ulcer increase or decrease with meals?
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Increases => weight loss
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One etiologic agent underlies duodenal ulcers - what is it?
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H. pylori (100%)
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2 pathogenic mechanisms are thought to lead to development of duodenal ulcer - what are they?
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Increased gastric acid secretion and decreased mucosal protection
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What tends to hypertrophy with duodenal ulcers?
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Bruenner's glands
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The margins of a doudenal ulcer are:
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clean and punched out
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The 4 common complications of of duodenal ulcers are:
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bleeding, penetration, perforation, and obstruction (not necessarily pre-cancerous)
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Does the pain of a duodenal ulcer increase or decrease with meals?
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Decreases => weight gain
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How is H.pylori infection treated?
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triple therapy (metronidazole, bismuth salicylate, amoxocillin or tetracycline) with or without proton pump inhibitor
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Does smoking effect peptic ulcer development?
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Yes, it is 2x as common in smokers
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The possible etiology of Crohn's disease is:
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Infectious
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The location and lesion type of Crohn's disease is:
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Skip lesions in any portion of GI tract, usually terminal ileum, SI, and colon. Rectal sparing.
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Gross Morphological features (6) of Crohn's disease are:
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Transmural inflammation, cobblestone mucosa, creeping fat, bowel wall tickening (string sign on x-ray), linear ulcers, and fissure. (FAT OLD CRONE SKIPPING DOWN A COBBLESTONE ROAD)
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The microscopic morphological features of Crohn's disease are:
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non-caseating granulomas
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The four major complications of Crohn's disease are:
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Strictures, fistulas, perianal diease, malabsorption leading to nutritional depletion.
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Two major extraintestinal manifestations associated with Chron's disease are:
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migratory polyarthritis and erythema nodosum
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The possible etiology of UC is:
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autoimmune
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Location and lesion type of UC is:
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continuous lesions of colon with rectal involvement
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The two gross morphological features of UC are:
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mucosal inflammation, friable mucosal pseudopolyps with freely hanging mesentery.
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The microscopic morphological features of UC are:
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crypt abcesses, ulcers
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3 severe complications of UC are:
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severe stenosis, toxic megacolon, and colorectal carcinoma
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Two major extraintestinal manifestations associated with UC are:
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pyoderma gangrenosum, sclerosing cholangitis
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