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32 Cards in this Set
- Front
- Back
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Takayasu's arteritis
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Granulomatous large vessel vasculitis involving aortic arch vessels
Young Asian F and children Absent upper extremity pulse Visual defects/stroke |
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Giant cell (temporal) arteritis
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Granulomatous large vessel vasculitis involving superficial temporal/opthalmic arteries
Thrombi contain microabscesses Adults >50 yo Temporal headache, jaw claudification Blindness ipsilaterally Polymyalgia rheumatica (musc/jt pain, normal creatine kinase) Increased ESR |
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Polyarteritis nodosa
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Necrotising medium sized vessel vasculitis involving renal, coronary, mesenteric arteries (spares pulm)
Middle-aged men, association w/ HBsAg Vessels at all stages of acute/chronic inflammation Focal vasculities = aneurysms Infarct in kidneys (renal failure), heart (MI), bowel (bloody diarrhea), skin (ischemic ulcer) |
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Kawasaki disease
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Necrotizing medium-sized vessel involving coronary arteries (eg thrombosis/aneurysms)
Children <4 yo Desquamating rash, swelling hands/feet, cervical adenopathy, oral erythema Abnormal ECG (acute MI) Corticosteroids may cause vessel rupture |
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Thromboangiitis obliterans (Buerger's disease)
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Medium-sized vessel w/ digital vessel thrombosis
Men 25-30 that smoke Foot claudification, Raynaud's phenomenon, ulceration, gangrene |
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Takayasu's arteritis "pulseless disease"
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Granulomatous large vessel vasculitis involving aortic arch vessels
Young Asian women/children |
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Takayasu's artertitis findings
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Absent upper extremity pulse
Visual defects Stroke |
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Giant cell (temporal) arteritis
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Granulomatous large vessel vasculitis involving superficial temporal and opthalmic arteries
Thrombi contain microabscesses Adults > 50 yo |
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Giant cell (temporal) arteritis findings
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Temporal headache, jaw claudication (pain chewing)
Blind ipislaterally Polymyalgia rheumatica (muscle/joint pain, normal serum creatine kinase) Increased ESR |
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Polyarteritis nodosa
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Necrotising medium sized vessel vasculitis
Renal, coronary, mesentaric (spares pulmonary) Middle-aged men Association with HBsAg |
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Polyarteritis nodosa findings
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Vessels at all stages of acute/chronic inflammation
Focal vasculitis produces aneurysms Organ infarct in kidneys (renal failure), MI, bowels (bloody diarrhea), skin (ischemic ulcer) |
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Kawasaki disease
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Necrotizing medium vessels involving coronary arteries (thrombosis, aneurysms)
Children < 4 yo |
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Kawasaki disease findings
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Desquamating rash, swelling hands/feet, cervical adenopathy, oral erythema
Abnormal ECG (MI) No corticosteroids! (risk vessel ruptures) |
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Thromboangitis obliterans (Buerger's disease)
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Necrotizing medium vessels with digital vessel thrombosis
Men 25-30 yo who smoke |
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Thromboangitis obliterans (Buerger's disease) findings
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Foot claudication, Raynaud's phenomenon, ulceration, gangrene
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Raynaud's disease
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Medium vessels involving digital vessels in fingers/toes
Young women (exaggerated vasomotor response to stress/cold) |
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Raynaud's disease findings
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Paroxysmal digital color changes (white-blue-red)
Ulceration/gangrene if chronic |
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Raynaud's phenomenon
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Medium vessels involving digital vessels in fingers/toes
Adults Secondary to other diseases (systemic schlerosis/CREST syndrome) |
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Raynaud's phenomenon findings
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Systemic schlerosis/CREST syndrome: digital vasculitis w/ vessel fibrosis, dystrophic calcification, ulceration, gangrene
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Wegener's granulomatosis
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Necrotizing medium and small vessels
Upper respiratory, lung, renal vessels |
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Wegener's granulomatosis findings
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Necrotizing vasculitis in upper respiratory (nasopharynx, sinuses, trachea), lower respiratory tract (pulmonary; infarct, pneumonia), kidneys (crescentic glomulonephritis)
Necrotizing granulomas in upper respiratory (saddle nose deformity) Lung c-ANCA Ab's Tx: corticosteroids/cyclophosphamide |
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Microscopic polyangiitis
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Small vessel
Skin, lung, brain, GI, venules, glomerular capillaries Precipitated by drugs(PCN), infections(Strep), immune disorders(SLE) |
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Microscopic polyangiitis findings
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Vessels at same stage of inflammation
Palpable purpura Glomulonephritis p-ANCA Ab's |
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Churg-Strauss syndrome
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Small vessels
Skin, lung, heart vessels |
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Churg-Strauss syndrome findings
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Allergic rhinitis, asthma
p-ANCA Ab's Eosinophilia |
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Henoch-Schonlein purpura
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Small vessels
Skin, GI, renal, joint vessels Children/young adults Most common vasculitis in children IgA immunocomplexes |
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Henoch-Schonlein purpura findings
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Palpable purpura of buttocks/lower extremities
Polyarteritis, glomulonephritis, GI bleeding |
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Cryoglobulinemia
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Small vessel
Skin, GI, renal vessels Adults Association with HCV, type I MPGN |
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Cryoglobulinemia findings
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Cryoglobulings: Ig that gel at low T
Palpable purpura, acral cyanosis of nose/ears, Raynaud's phenomenon (reverses in warmth) |
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Serum sickness
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Small vessels
Immunocomplex deposition in vessels Complication of Tx for rattlesnake venom w/ horse/sheep anti-venom |
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Serum sickness findings
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Fever, urticaria, vasculitis, arthralgia, GI pain w/ melena (tar face)
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Infectious vasculitis
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Small vessels (skin)
Rocky Mt spotted fever: tick transmits Rickettsia (invade endothelial; petichiae on palms spread to trunk) Disseminated meningococcemia (N meningiditis) Capillary thrombosis = hemorrhage into skin = ecchymoses |
