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34 Cards in this Set
- Front
- Back
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4 mediators that attract neutrophils |
LTB4 C5A IL-8 Bacterial products |
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Prostglandin for pain and fever |
PGE2 |
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Substrate for COX and LT pathway |
Arachidonic acid |
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Receptor on Macrophage that react to PAMP |
Toll like receptor |
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TLR binds to PAMP produces |
Nf-KB |
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PAMP on gram (-) bacteria |
LPS |
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LPS' receptor (TLR) |
CD14 |
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Key activators of mast cells |
C3a and C5a, tissue trauma, crosslinking of antigen with IgE |
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Classic complement activation |
C1 binds to IgG or IgM (GM creates classic Cars) |
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Alternative pathway for complement activation |
Microbial product activation |
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Mannose-binding lectin complement activation |
MBL binds to mannose on organisms |
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Complement cascase |
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Opsonin for phagocytosis |
C3b |
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Chemotactic for neutrophils |
C5a |
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Trigger mast cell degranulation |
C3a and C5a |
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Final product of complement cascase |
Membrane attack complex (MAC) Punches holes into the membrane causing cell death |
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Mediators of pain |
PGE2 and bradykinin |
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Hageman factor |
Activated by exposure to subendothelial or tissue collagen 1) activates complement 2) activates coagulation 3) kinin system |
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Macrophage products that cause fever |
TNF and IL-1 |
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Neutrophil peak |
24 hrs |
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Macrophage peak |
2-3 days |
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Phases of neutrophil recruitment |
1) margination 2) rolling 3) adhesion 4) transmigration and chemotaxis 5) phagocytosis |
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P selectin released from |
Weibel-Palade body Mediated by histamine |
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E selectin induced by |
TNF and IL-1 |
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Upregulates integrins? |
C5a and LTB4 |
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Integrins upregulates by |
IL-1 and TNF |
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Leukocyte adhesion deficiency Cardinal manifestation |
Delayed separation of umbilical cord Defect of integrins (CD18 subunit) |
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Impaired phagolysosome formation |
Chediak-Higashi syndrome |
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Induces macrophage to undergo resolution and healing after acute inflammation |
IL-10 and TGF-B |
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Induces Macrophages to continue acute inflammation |
IL-8 |
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Interleukin, CD8+ T cell activator |
IL-2 |
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Macrophage activator |
IFN-y |
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Interleukin functions |
IL-1 fever IL-2 activation of CD4 helper T cells (2nd signal) IL-4 (class switch from IgG to IgE) IL-5 (maturation of B cells to plasma cells, IgA class switching) IL-8 Neutrophil recruitment IL-10 inhibits TH1 phenotype IL-12 induces TH1 subtype |
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Macrophage to epithelioid histiocytes mediator |
IFN-y |
