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10 Cards in this Set
- Front
- Back
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3 Systems of the Immune System? |
1. Skin and mucous membranes 2. Mononuclear Phagocyte System 3. Lymphoid System 4. Bone Marrow |
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Function of skin and mucous membranes (component 1) |
- first line of defense -mechanical and chemical barriers if intact -prevent pathogens from entering the body -lines outer body, GI and resp system |
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Function of Mononuclear phagocyte System |
--monocytes from blood move to organs& tissues to become “macrophages” (have different names in different parts of the body). -macrophages & dendritic cells 1st to come across pathogen or foreignantigen and theycommunicate this to other immune cells through chemicals called “cytokines”, & present antigen to specificimmune cells.-macrophages play key role inphagocytosis and prepare the area to “heal”7 |
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Components of Lymphoid System |
-Tonsils and spleen (only outgoing lymphatic vessels -lymph node, afferent and efferent lymph vessels allowing lymphocytes to travel to other tissues Peyer's patches found in GI, resp, and urogenital tracts (mainly B cells that produce antibodies) |
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Function of Bone Marrow |
-found in all bones of body, main function is hematopoiesis (creation of blood cells) -Red marrow found in adult pelvis, sternum, ribs, cranium, end of long bones, and vertebrae |
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Cells of the mononuclear phagocyte system |
brain: microglial cells neck: cervical lymph nodes lung: alveolar macrophages liver: kupffer cells Spleen: macrophages Kidney: mesangial phagocytes Joint: synovial A cells Blood: monocytes Lymph node: resident and recirculating macrophages Skin: langerhans cells |
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Function of Lymphoid System |
Thymus gland and bone marrow -T cells transfer to thymus gland to develop -B cells and Natural Killer cells (NK) stay in bone marrow to develop -all originate in bone marrow -T cells travel and B cells stay usually in lymph node to release antibodies |
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What are the secondary lymphoid organs? |
-tonsils -peyer's patches -spleen |
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Types of Leukocytes? |
-Neutrophils -Basophils (Mast cells) -Eosinophils -lymphocytes -monocytes, macrophages -dendritic cells |
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Function: Neutrophils |
-1st toappear after injury; involved in phagocytosis -make up 60-80% of WBC count-“Bands”Þimmature neutrophils; “shift to the leftof normal” diagnostically significant indicates bacterial infectiondue to increased numbers of neutrophils in production -release chemicals to destroymicroorganisms, Butcan also cause damage to normal tissueduring inflammation -neutrophils die when fight infection. |
