Pathology

Front 1

collagen

Back 1

a family of closely related proteins forming the white fibers of connective tissue, cartilage and bone

Front 2

basement membrane

Back 2

delicate structure at the interface between cells and stroma containing collagen, laminin and other matrix components

Front 3

fibronectin

Back 3

a family of glycoproteins in with specialized binding sites

Front 4

proteoglycans

Back 4

molecules of the extracellular matrix formed by long. unbranched, polysaccharide chains which are covalently bound to a protein core

Front 5

integrins

Back 5

a family of cell surface receptors that bind components of the extracellular matrix

Front 6

cytokine

Back 6

soluble proteins that bind to specific cell surface receptors, stimulate mitogenic (growth) factors, in order to modulate cell behavior during embryogenesis, normal tissue maintainance, inflammation, immune responses, and wound healing

Front 7

healing

Back 7

a restoration of integrity to a injured tissue

Front 8

contraction

Back 8

reduction in the size of a wound mediated principally by myofibroblasts

Front 9

myofibroblast

Back 9

cell with features of fibroblasts and smooth muscle cells that migrate into a wound 2-3 days after injury; their active contraction decreases the size of a wound

Front 10

repair

Back 10

the orderly process by which a wound is eventually replaced by a scar

Front 11

erosion

Back 11

a wound in which only the lining epithelium is affected

Front 12

granulation tissue

Back 12

formed in the initial response to tissue injury; consists of a richly vascular connective tissue that contains new capillaries, abundant fibroblasts, and inflammatory cells

Front 13

angiogenesis

Back 13

pronounced vascular proliferation starting 48-72 hours after injury and lasting several days

Front 14

regeneration

Back 14

the renewal of a lost tissue or part in which the missing cells are replaced by identical ones

Front 15

dehiscence

Back 15

bursting of a partially-healed wound