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5 Cards in this Set
- Front
- Back
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Sclerosing Lymphocytic
LobulitClinical: Young – middle age, mass or nodularity, pain, may be bilateral. Insulin dependent diabetes, Hashimoto’s thyroiditis, HLA-DR 4 or 5 Micro: circumscribed, perivascular and perilobular lymphocytic infiltrate, lobular atrophy, stromal fibrosis, epitheliod fibroblasts (SMA +, CK -) myofibroblastic origin.is |
Granulomatous Mastitis
Systemic granulomatous disease Infections (mycobacterial and fungal) Idiopathic granulomatous mastitis – palpable mass, often tender, lobulocentric, associated with recent pregnancy. |
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3-4 cell thickness – mild hyperplasia – no
increase risk of carcinoma Greater than 4 cell thickness – florid or moderate hyperplasia – Slight risk of cancer (1.5 to 2 X) |
Ductal hyperplasia (- atypia)
Architectural Patterns a. Irregular peripheral fenestrations b. Streaming of epithelial cells c. Overlapping nuclei Cytologic features a. Multiple cell types b. Variation in epithelial cells (metaplastic changes) c. Indistinct cytoplasmic borders d. Nuclear irregularity e. Foamy macrophages in lumen The Osler Institute The Osler |
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Family History
5-10% are hereditary BRCA1 and BRCA2 Li-Fraumeni syndromemutation of P53 gene (17p13.1) Cowden’s syndrome – PTEN gene on 10q23.3 ATM gene 11q22-23 Peutz-Jeghers – STK11/LKB1 gene on (19p13.3) |
tubular carcinoma has excellant prognosis
colloid carcinoma has excellant prognosis |
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medullary carcinoma
Associated with BRCA1 gene. IHC: ER & Her2 -; P53 + Prognosis: more favorable than ductal cancer. |
Adenoid cystic carcinoma
Gross: well circumscribed Micro: similar to adenoid cystic of salivary gland, biphasic nature of cells comprising the cell nests, central basaloid cells and peripheral larger epithelial cells IHC: basaloid cells CK14 +, epithelial cells CK7 + P63, SMA: +, SMMHC & calponin: - Prognosis: excellent. |
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Metaplastic Carcinoma
Prominent non epithelial component, spindle cells, squamous cells and heterologous elements. More aggressive than invasive ductal Ca Metastasis is hematogenous Sarcomatous component may resemble fibromatosis, fibrosarcoma, MFH and other sarcomas. Look for epithelial components. IHC: HMWCK and P63 + |
free
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