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15 Cards in this Set
- Front
- Back
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Basic properties of self tolerance?
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The same as an immune response.
- Antigen-specific - Memory - Dichotomy (B vs T cell), can be split tolerant... |
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Pernicious Anemia
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B12 absorption failure
Plasma cells produce auto-Ab against IF in gut |
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Autoimmune Hemolytic Anemia
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RBCs get opsonized / phagocytized
See white knuckles/fingers, then blue (no O2) |
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Diabetes Type 1 Etiology?
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Reduced beta cells (-->insulin dependent)
Genetics / Autoimmune (MHCII) / Viral/Chemical insult |
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Diabetes Type 1: autoimmune mechanism and outcomes?
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CD4, CD8, AND Auto-Ab's against islet cells.
Renal and Athero sclerosis Retinopathy (blindness) Aggressive periodontal disease |
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Myasthenia Gravis
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Auto-IgG's bind to AChR's
Ptosis, if severe, resp problems Tx: anti cholinesterases and immune suppressants |
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Hashimoto's Thyroiditis
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Thyroid gets replaced by lymphocytic infiltrate.
T-cells, Plasma cells, Auto-Ab's Activated macros cause injury Hypothyroidism (T3/4), non-tender goiter. |
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Graves Disease
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Auto-Ab's bind to TSH-receptor and ACTIVATE it
Hyperthyroidism Exopthalmos, inc metab/HR/weight loss W>M Goiter Fine hair, menstrual messed up Lose primaries fast, adult dentition comes in early. |
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Rheumatic Fever
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5-15yo, after a Strep A infection
M-protein on strep induces Ab x-rxn w/ cardiac epitopes Acute Myocarditis/Arrhythmias Aschoff Bodies - Pathognomonic (necrosis, becomes scar) |
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Sjogren's Syndrome
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Primary = without RA or SLE
Secondary = with them Dry eyes / dry mouth Burning pain, ulcerations... B-cell dysfunction. Chronic disease, only replacement tx. |
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Multiple Sclerosis
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Demyelination plaques
Axon itself is okay Auto CD4, CD8, macrophages gait/paralysis/incontinence |
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Systemic Lupus Erythematosus
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Rash, glomerulonephritis, arthritis, from vasculitis
90% women "Anti-Nuclear Antibodies" ANA IIF detects it Immune Complexes (Type III) |
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Signs and symptoms of SLE?
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RBC and WBC casts in urine
Serosis Myocarditis / resting tachy / deposits on heart valves Oral ulcer / erythema / keratosis Skin rashes + butterfly |
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Discoid Lupus Erythematosus
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Specific form of SLE that affects ONLY the skin.
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Rheumatoid Arthritis
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Systemic, w/ chronic inflamm
Nonsupp proliferative synovitis "Pannus" - high vasc messed up synovium W>M T's, macros, cytokines --> damage, but B's/Ab's there too Immune complexes (type III) Sub-cut nodules @ extensor= pathogonomic TMJ involved in late stages |
