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17 Cards in this Set
- Front
- Back
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TLR-1:TLR-2 heterodimer
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gm + bacterial triacyl lipopeptides
fungi membrane-bound |
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TLR-2:TLR-6 heterodimer
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gm + bacterial diacyl lipopeptides
fungi membrane-bound |
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TLR-3
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viral dsRNA
endosomal |
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TLR-4:MD-2 complex
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bacterial LPS
membrane-bound involved in septic shock |
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TLR-5
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flagellin
membrane-bound |
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TLR-6
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gm + bacterial diacyl lipopeptides
fungi membrane-bound only found in assoc w/TLR-2 |
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TLR-7
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viral ssRNA
endosomal |
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TLR-9
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viral unmethylated CpGDNA
endosomal |
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What changes in phagocytes does TLR activation induce?
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NFkB transcription factor activation -->
localization of MHC I/II + peptide complexes to cell surface express costimulatory surface molecules CD80, CD86 secretion of cytokines IL-1, IL-12, IL-6 etc. + pro-inflammatory genes |
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NOD2
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muramyl dipeptide
both gm + and - bacteria cytosolic |
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NOD 1
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iE-DAP, Diaminopimelic acid (peptidoglycan)
gm - bacteria only (NOD2 both + / - ) cytosolic |
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RIG-I
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viral dsRNA
cytosolic IRF3 and IRF7 pathway |
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MDA-5
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viral dsRNA
cytosolic IRF3 and IRF7 pathway |
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TLR-8
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G-rich oligonucleotides
membrane-bound |
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Dectins
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beta-glucans
fungi |
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C1q
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Antigen:Antibody complexes (binds Fc region of IgM or IgG)
binds pathogen membrane w/low affinity free in plasma |
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MBL
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mannose/fucose residues on bacterial surfaces
free in plasma |
