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97 Cards in this Set
- Front
- Back
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Job's syndrome is a defect in 2
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chemotaxis, inc IgE
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Absolute ct eqn
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%WBC x total WBC
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What is a leukemoid rxn
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Benign exaggerated leukocyte response
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Leukoerythroblastic rxn in F > 50 usu due to
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mets breast CA
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Effect of cortisol on eosinophils
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dec
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If have basophilia, consider
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MPD
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describe atypical/reactive lymphocytes 3
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ameboid (dutch skirt), inc size, pale gray-blue
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1st morph cell of WBC
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myeloblast
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2 stim chemicals
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G-CSF, GM-CSF
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Chediak Higashi genetics
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auto R
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Morph?
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Large granules
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Pelgeur-Huet anomoly genetics
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auto dom
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Morph?
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Hyposegmented neutrophils (but ALL of them must be like this)
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Chronic v. acute lymphadenitis
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Chronic is nontender, acute is tender
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Which is malignant?
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chronic
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genetics of Gaucher dz?
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AR
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Patho?
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glucocerebroside accumulates in phagocyte
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Morph?
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Wrinkled-paper cytoplasm
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Epi for HCL?
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M in 40s
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Morph?
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Cytoplasmic projections
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primary site for neoplastic cells
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HCL
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Dx stain - KNOW THIS
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TRAP stain
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Tx?
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purine analogs!!
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most common primary neoplasm in spleen
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cavernous hemangioma
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3 types of thymic cysts
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benign, striated, ciliated
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CD21 serves as
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EBV-R
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Test for mono
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IgM aginast horse RBC
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most common leukemia in children
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ALL
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most common leukemia in 15-60
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AML
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most common leukemia in 40-60
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CML
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most common leukemia in 60+
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CLL
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most common leukemia
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CLL
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leukemia inv CNS and testis point to
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ALL
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Most important test for leukemia Dx
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BM exam
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What is the key finiding for acute leukemia
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blasts > 20%
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is this found in chronic
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No! blasts <10%
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myeloid d/o are d/o of
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neoplastic stem cells
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Most common gene of CML
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t(9;22)
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CML blast crisis shows
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myeloblasts or lymphoblasts w/ no Auer rods
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CML is the only leukemia with
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thrombocytosis
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Leukocyte ALP would be
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dec b/c neoplastic can't produce
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MMM is mostly due to
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Jak2 mutation
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which Chr
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chr 9
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Also implicated in
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PV, ET
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What's the consequence
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EMH -> massive splenomegaly
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RBC morph?
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tear drop
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Complication of MDS
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progression to acute leukemia
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M3
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acute promyelocytic (APL)
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M5
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acute monocytic (AMoL)
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Gene change in APL
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t(15;17)
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Are auer rods in AML or CML or both
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Just AML
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most common type ALL
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Tdt & CD10 (CALLA) +
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what gene offers favorable prognosis of ALL
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t(12;21)
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adult T cell leukemia is assoc w/
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HTLV-1
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Gene inv?
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TAX gene inh p53
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bone lesions seen?
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lytic -> hypercalcemia
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CLL inc or dec IgG
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dec b/c neoplastic can't produce plasma cells
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Dz of germinal follicle 2
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Reactive lymphadenitis, follicular B cell lymphoma
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Dz of paracortex 2
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reactive hyperplasia, T cell lymphoma
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Dz of sinus 4
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Mets, sinus histiocytosis, Langerhans histiocytosis, histiocytic lymphoma
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key nodal groups in primary/mets CA
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p 240
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axillary
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met breast
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cervical 2
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met H&N, HL
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epitrochlear
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NHL
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hilar 2
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met lung, sarcoid b/l
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Inguinal 2
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met vulvar, met penis
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mediastinal 3
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met lung, HL, T-cell lymphoblastic lymphoma
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para-aortic 2
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met testicular, Burkitt's
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R supraclavicular 3
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met lung, met esophagus, HL
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submental
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met SCC
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tonsillar
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met SCC of oral cavity
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Virchow's (L supraclavicular)
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met abdominal
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Nodes containing macrophages with melanin signal
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malig melanoma
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granulomatous microabscess in regional LN cause by
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Bartonella (cat-scratch)
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sinus histiocytosis in axillary LN is a favorable sign in
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breast CA
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extra-nodal sites of NHL 3
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stomach, CNS, peyer's patches
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2 autoimmune conditions prone to NHL
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Sjogren's, Hashimoto
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Microbes related to NHL
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H. pylori, EBV
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starry sky appearance (histiocytes w/ debris)
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Burkitt lymphoma
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gene common in Burkitt
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t(8;14)
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diffuse large b cell lymphoma derived from
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germinal center
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lymphoma derived from MALT
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marginal zone
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gene seen in follicular lymphoma?
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t(14;18)
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age range of pt w/ small lymphocytic lymphoma
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> 60
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what is mycosis fungoides?
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neoplasm of CD4 cellls
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in leukemic phase, it's called
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Sezary syndrome
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most common type of HL
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nodular sclerosing (ant mediastinal mass + single group above diaphragm)
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Is it more present in F or M
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F
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Neoplastic cell of HL?
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Reed sternberg
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Histiocytes always have
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CD1+
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How do they look on EM?
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Have Birbeck granules (look like tennis racket)
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Classic triad of Hand-Schuller-Christian dz
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lytic lesions of skull, DI, exopthalmos
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2 signs of urticaria pimentosum
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dermatographism, lesions stay hyperpigmented
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What are bence jones proteins?
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light chains in urine
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Punched out lytic lesions indicate
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MM
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Niemann-Pick is a d/o of
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sphingomyelin; lysosomes
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How do cells look?
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soap bubbly
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