Patho Mod 3

Front 1

what are the 3 stages of wound healing?

Back 1

1.actue inflammatory phase
2.proliferative phase-beginning of fibroblastic activity and anglogensis by the epithelial cells
3.maturation phase-involves collagen synthesis and breakdown

Front 2

is this resolution or repair?
the most favorable outcome of healing, complete return to normal

Back 2

resolution

Front 3

is this resolution or repair?
replacement of damaged and destroyed tissue with scar tissue

Back 3

repair

Front 4

what are the 3 repair healings?

Back 4

primary
secondary
tertiary

Front 5

this repair healing consists of taking the place when wound margins are neatly approximated in wounds with minimal tissue loss, require very little sealing and shrinking, ex: paper cuts

Back 5

primary

Front 6

this repair healing consist of wounds that have significant tissue loss, requires more tissue replacement, take place from edges inward, from bottom upward ex:stage 4 pressure sore

Back 6

secondary

Front 7

this repair healing consist of healing occurs with the delayed suturing of a wound in which 2 layers of granulation tissue are sutured together ex: contaminated would is left open and sutured close after the infection is controlled

Back 7

teritary

Front 8

what are some local and systemic factors that affect wound healing:

Back 8

shape and location
inadequate blood supply
age
nutritional status
infection
smoking
obesity
diabetes
poor general health

Front 9

separation and disruption of previously joined wound edges

Back 9

dehiscence

Front 10

exaggeration of normal presence of myobibroblast and sustained cell contraction, severe deformity,

Back 10

contracture

Front 11

scar tissue that extends past the original location of injury

Back 11

keloid

Front 12

What are some organs and cellular components of the immune system?

Back 12

bone marrow(B cell maturation), thymus(T cell maturation), nodes(site for Ag contact and response harbor T and B cells), tonsils, spleen(filter Ags from blood), T and B cells, macrophages, dendritic cells

Front 13

T cells originate in the ______ and their function is to?
B cells originate in the _____ and their function is to?

Back 13

thymus, protection against viruses
bone marrow, produce a distinct antibody molecule

Front 14

this is a substance foreign to the host that can be stimulated an immune response

Back 14

antigen

Front 15

what are the 3 primary immunocytes?

Back 15

B T and natural killer

Front 16

this immunocyte polices the blood and lymph, target virus infected cells and release perforins

Back 16

natural killer

Front 17

this immunocyte recognizes native Ag, producing Abs against it. have plasma cells and memory cells

Back 17

B cells

Front 18

this immunocyte recognizes processed Ag, and response by producing cytokines

Back 18

T cells

Front 19

what are the classes of immunoglublins?

Back 19

IgM
IgG
IgE
IgA
IgD

Front 20

this immunoglublin is the first circulating and the first to be made by a newborn and the primary response

Back 20

IgM

Front 21

this immunoglobulin is the only one to cross the placenta, and is the secondary response most abundant

Back 21

IgG

Front 22

this immunoglobulin releases histamine and other inflammation allergy mediators

Back 22

IgE

Front 23

this immunoglobulin is the 2nd most abundant and found in mucus mem.

Back 23

IgA

Front 24

this immunoglobulin is found on cell membranes of B lymphocytes, differentation and maturation of B cells, dont really know the function

Back 24

IgD

Front 25

this system inactive until and antigen antibody reaction causes the complement system to activate

Back 25

complement system

Front 26

immune responses that are initiated through specific Ag recognition by T cells are termed?

Back 26

cell mediated immunity

Front 27

major effects of the cell-mediated immune response?

Back 27

cytotoxicity
memory
control
hypersensitivity

Front 28

what are the 5 mature T cells

Back 28

lymphokine-producing cells
macrophages
CD8 cytotoxic cells
CD4 helper cells
suppressor T cells

Front 29

this is the ability of the immune response to be nonreactive to selfr while producing immunity to foreign agents

Back 29

tolerance

Front 30

this type of acquired immunity is produced by the host either after natural exposure or immunizations

Back 30

active

Front 31

this type of acquired immunity does not involve hosts immune response protective preformed Abs are transferred to the recipient via naturally or artifically and is temporary

Back 31

passive

Front 32

Passive natural immunity is transferred how?
Passive artifical immunity is transferred how?

Back 32

maternal immunoglobulins across placenta IgG, or from breast milk
injection of preformed serum Abs

Front 33

Active natural immunity is transferred how?
Active artifical immunity is transferred how?

Back 33

contact w. Ag through infection
immunization with Ag

Front 34

How is the transfer of passive immunity from mother to infant?

Back 34

across the placenta IgG

Front 35

what does it mean if you have IgM and IgA in the infants cord blood?

Back 35

immunoglobulins are of fetal orgin so the baby was exposed to intrauterine infection

Front 36

what are some factors contributing to the elderlys reduced ability to mount an inflammatory response

Back 36

risk for impaired wound healing
increased incidence of other systems
fat decreases(not as much protection)
declining macrophage function

Front 37

a progressive dysfunction of the immune system from age related changes

Back 37

senescence

Front 38

what are some changes that occur in the agign immune system?

Back 38

more susceptible to dz
autoimmune disease increase
decreased response to immunizations

Front 39

why does the autoimmune dz increase as we age?

Back 39

lose tolerance to self