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15 Cards in this Set
- Front
- Back
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Chronic Myeloid Leukemia
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-Philadelphia Chromosome in granulocytes
-15% of all leukemia cases in US -Age of onset 40-50 -Rare in childhood/adolescence -Acute is more symptomatic |
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Leukemia
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-Circulating tumors
-Involve blood and bone marrow -Disseminated at beginning of disease |
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Lymphoma
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-Lymph Tissues
-Disseminates to other sites at diagnosis |
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Myeloid
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-RBC's, platelets, monocytes, granulocytes
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Lymphoid
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T-cells, B-cells, NK cells
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Non-Hodgkin's Lymphoma
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B-Cell, T-Cell and NK Cell
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Hematologic Neoplasms Diagnosis
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Leukopenia, Anemia, Thrombocytopenia, Netropenia
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Leukopenia
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lymphadenopathy, joint swelling and pain, weight loss, anorexia, hepatomegaly, splenomegaly
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Anemia
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pallor, fatigue, malaise, shortness of breath, decreased activity tolerance
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Thrombocytopenia
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a platelet count below 20,000 cells/μl, petechiae, easy bruising, bleeding gums, occult hematuria, retinal hemorrhages
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Neutropenia
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absolute neutrophil count <500 cells/μl
Evaluation of peripheral blood sample key aspect of diagnosis Definitive diagnosis is usually made after bone marrow aspiration or lymph node biopsy |
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Chronic Myeloid Leukemia
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Fatigue, weight loss, bleeding, splenomegaly, weight loss, sweats
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Acute Myeloid Leukemia
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80% are adults, age of onset is 64, transformation of myeloid stem cell, bone pain, thrombocytopenia, anemia, similar to ALL, infections at GI, GU, skin, resp. tracts
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Acute Lymphoblastic Leukemia/Lymphoma
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Lymphoid cell malignancy, 80% b-cell 20% T-cell transofrmation, abnormal lymphoblasts look like immature lymphocytes, mostly children
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ALL
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most common malignancy, 2nd leading cause of death
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