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17 Cards in this Set
- Front
- Back
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Name the cardinal signs of inflammation
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redness
swelling heat pain loss of function |
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what are the 2 components of acute inflammation?
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vascular stage
cellular stage |
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first WBC to arrive at inflammation site
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Neutrophil
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These cells increase in number during allergic reactions and parasitic infections
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eosinophils
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these cells contain histamine and produce symptoms assoc. with allergic rxns.
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basophils
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which chemical mediators are resposible for fever?
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IL1
IL6 TNF |
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which chemical mediators are resposible for pain?
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Bradykinin
Prostaglandins |
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which chemical mediators are resposible for swelling, redness, and tissue warmth?
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Histamine
prostaglandins leukotrienes bradykinin PAF |
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how does aspirin and NSAIDs work?
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by inactivating an enzyme in the cyloocygenase pathway that produces prostaglandins
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where does arachinodic acid come from?
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Membrane phospholipids
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which pathway forms leukotrienes
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lipoxygenase
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what is the most obvious sign of the acute phase response?
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Fever
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which cytokines are involved in the acute phase response?
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IL1
IL6 TNF |
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which proteins are elevated during the acute phase response?
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C-reactive protein
Fibrinogen These reflect an accelerated ESR |
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what are the systemic effects of the acute phase response?
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>ESR
fever lethargy > levels of CRP Leukocytosis in some cases, leukopenia |
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what is thromboxane?
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a vasoconstrictor and a potent hypertensive agent, and it facilitates platelet aggregation
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Most Common cause of nosocomial bacterial pneumonia
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Streptococcus pneumoniae (pneumococcus)
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