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31 Cards in this Set
- Front
- Back
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Anaplasia
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poorly differetiatied
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Neoplastic
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uncontrolled growth
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Metaplastic
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change of cell type
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Basal cell carcinoma of skin
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rarely metastasizes
highly invasive |
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Borderline tumors of ovary
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rarely go into ovarian stroma
metastasize to abdomen via seeding |
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Giant cell tumors of bone
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histology benign
occasionally metastasize |
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carcinoma in situ
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severe dysplasia with high likelihood to INVASIVE CANCER
basement mem. still intact |
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hamaratoma
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types of cells normal
severe dysplasia |
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Choristoma
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ectopic rest of normal tissue
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Pseudosarcomatous proliferations
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rapid growth
hypercellular high mitotic rate mild atypia |
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desmoplastic
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extremely fibrinous response to invasive tumor
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-sarcoma
-carcinoma |
SARCOMA- mesenchymal tissue
CARCINOMA- epithelial tissue |
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smooth muscle malignant tumor
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leimyosarcoma
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striated muscle malignant tumore
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rhadbomyosarcoma
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seminoma
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testicular cell carcinoma
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testicular cell carcinoma
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seminoma
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staging
grading |
STAGING- how invasive is it?
size + extent + metastasis (TNM) GRADING- degree of differentiation |
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which has more predictive value: staging or grading?
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STAGING- how invasive is it?
size + extent + metastasis (TNM) |
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grading tumors
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histological examination of tumor
how ANAPLASTIC is it? |
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pseudomyxoma peritnei
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mucus secreting tumor in the peritomneum
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Lymphatic spread
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more common in carcinomas
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where in lymph node do you mind metastasis
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subcapsular spread
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hematogenous spread
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initial mode of spread in sarcomas
generally venous invasion arterial less common |
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retinoblastoma system
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Rb + P ---> dissociates from E2F
TRIGGERS ENTRY INTO S-CYCLE tumor-supressor gene |
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p53 dysfunction
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generally spontaneous
rarely inherited MUST BE BOTH GENES |
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mutation w/ XERODERMA PIGMENTOSUM
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def. in nucleotide excision repair
(NER) |
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tratuzumaub
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monoclonal Ab-(Her-2)
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Her-2
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protooncogene CR#17
25% breast cancers target with TRATUZUMAUB |
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CML caused by
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BCR on CR#22 to ABL on CR#9
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Philidelphia Chromosome
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CML
trans. CR#22 to CR#9 |
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Imanitib
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Gleevec
TK-inhibitor for CML |
