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22 Cards in this Set
- Front
- Back
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Never Let Monkeys Eat Bananas
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-Neutrophils
-Lymphocytes -Monocytes -Eosinophils -Basophils |
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Neutrophils
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-First cells to respond
-Kill bacteria -Phagocytosis -Granules kill with superoxide burst -Release leukotrienes to attract other cells |
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What are leukotrienes?
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-They are eicosanoid lipid mediators produced from archidonic acid
-They act as autocrine/paracrine signals in inflammation |
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Basophils
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-Act like mast cells
-Granules contain histamine/heparin -Release Leukotrienes |
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Eosinophils
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-Phagocytose AG/AB complexes
-Granules contain MBP and eosinophilic cationic protein |
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Lymphocytes
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-Agranular
-Large -Responsible for making ABs -Participate in cell-mediated immunity, direct killing of bacteria, cells containing viruses, and CA cells |
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How do T cells attack?
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They attack directly by physical contact
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How do B cells work?
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They transform into plasma cells and secrete ABs; the AB coated bacteria are then phagocytosed
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What do monocytes do?
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They migrate into tissues and become macrophages.
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What do platelets release?
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-PDGF: stimulate tissue healing
-Ca2+: key clotting factor -ADP: promote platelet aggregation -Serotonin & epi: vasoconstrictors |
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What cell line do RBCs derive from?
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Myeloid
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Which cell is committed?
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Precursors (blast)
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What hormone promtes teh growth and differentiation of erythrocyte precursors cells into erythrocytes?
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Erythropoietin
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What are the effects of erythropoietin?
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1. Increase the number of proerythrocytes
2. Accelerate Hb synthesis 3. Allow premature release of reticulocytes from marrow into circulation |
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What are the basic steps of hematopoiesis?
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1. Pluripotent stem cell makes multipotential cell
2. Multipotential cell makes progenitor cells 3. Progenitor makes precursor (blast) cells 4. Blast cell forms mature cell |
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What is a reticulocyte?
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An immature RBC that contains RNA, mitochondria, and ~80% hemoglobin; it is also larger
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What is serum?
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Plasma with the clotting factors removed.
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What is plasma?
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Non-cellular component of blood
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What is derived from the lymphoid cell?
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Lymphocytes
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What is derived from the myeloid cell?
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Platelets, RBCs, granulocytes, and monocytes
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What are the main components of plasma?
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1. Water
2. Ions 3. Organic ions (AAs, proteins, glucose, lipids, nitrogenous wastes) 4. Elements and vitamins 5. Gases |
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What are the formed elements of blood?
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-RBCs: 5,000,000/mm3
-WBCs: 7000/mm3 -Platelets: 250,000/mm3 |
