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11 Cards in this Set
- Front
- Back
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what are the 3 categories of benign epithelial lesions? how are the grouped?
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nonproliferative change
proliferative change atypical hyperplasia grouped according to the risk of dev BC |
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describe fibrocystic change grossly
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"lumpy bumpy breast" on palpation; ill-defined, diffuse incr in consistency
very common presents with pain; my mimic CA ceases with menopause sx tx with oral contraceptives |
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from where do cysts arise?
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lobules
NOT DUCTS |
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what are 3 patterns of fibrocystic change?
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cyst formation (w/ apocrine metaplasia)
fibrosis adenosis (incr # of acini per lobule) |
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how do cysts form? how do they appear grossly?
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dilation and unfolding of lobules
lobules coalesce to form lg cysts unopened cysts= blue-dome cyst |
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describe apocrine change in a cyst
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dilated area/cyst lined with metaplastic epithelial cells (eosinophilic b/c of incr mt)
secretory debris oftens contains calcifications |
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what is adenosis?
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incr number of glands per unit area
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what is synonymous with atypia?
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dysplasia
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proliferative breast disease without atypia: which types have increased risk of invasive cncer
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- hyperplasia of ductal epithelium
(can be mild or florid) - sclerosing adenosis (sclerosing adenosis and florid incr riskk of invasive CA) |
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describe mild epithelial hyperplasia
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lumen filled with heterogenous population of cells: luminal and myoepithelial types
slit-like fenestrations at periphery indiv cells still look relatively normal |
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how is sclerosing adenosis different from invasive carcinoma?
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unlike carcinomas, acini are in swirling pattern with well circumscribed outer border
also, have both myoepithelial and glandular cells |
