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11 Cards in this Set
- Front
- Back
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peripheral smear of megaloblastic anemias?
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1. macroovalocytes (MCV>100)
2. Howell Jolly bodies (DNA fragments still present in RBC) 3. Hypersegmented neutrophils |
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hypersegmented neutrophils
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megaloblastic anemia
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what are Howell jolly bodies?
where do you see them? |
-Howell Jolly boides=DNA fragments still present in RBC's
Seen in: -Megaloblastic anemia, -myodysplastic anemia (sickle cell) -Asplenia |
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Sx of vit B12 def
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neurological problems (imagine Haley with neurological problems)
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lab features of pernicious anemia
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1. Auto-Ig (Anti-parietal cell, Anti-IF)
2. Achlorhydria |
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Pathophys of megaloblastic anemias
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defective DNA syn and nl RNA/protein syn
-->affecgts myeloid cells -->ineffective hematopoesis (RPI<2) |
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Sx of megaloblastic anemia
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dyspepsia and glossitis
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neurologic Sx seen in what Dz?
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Vit B12 def (but not in folate def!)
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lab features of folate def?
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increased urinary excretion of FIGLU
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what is aplastsic anemia
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disturbance in prlif and diff of stem cells
-->non-fxn'al RBC's |
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et of aplastic anemia
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acquired (MC),
inherited (Fanconi's anemia) |
