Path Final Study 1

Front 1

Most common soft tissue of oral cavity, not encapsulated, hyperkeratosis from secondary trauma, atrophy of rete ridges

Back 1

Fibroma

Front 2

Fibrous CT tumor, younger age, GINGIVA, numerous large stellate fibroblasts in superficial CT

Back 2

Giant cell fibroma

Front 3

Like giant cell fibroma, but in cuspids

Back 3

Retrocuspid papilla

Front 4

Reactive hyperplasia of fibrous CT and epithelium, in alveolar mucosa, irregular hyperplasia of rete ridges, hyperparakeratotic

Back 4

Epulis fissuratum

Front 5

Wearing denture 24 hrs/day, palate, erythematous lesions = secondary candidiasis, PSEUDOEPITHELIOMATOUS

Back 5

Inflammatory papillary hyperplasia

Front 6

Can develop anywhere on body, most common site = skin on extremities, buccal mucosa/vestibule = most common location, cellular proliferation of spinde shaped fibroblastic cells w/ vesicular nuclei

Back 6

Fibrous histiocytoma

Front 7

Locally aggressive proliferation of fibrous CT , NO hyperchromatism or pleomorphism, no metastasis

Back 7

Fibromatosis

Front 8

Myofibroblasts, rare neoplasms that <3 head and neck, spindle shaped cells with both fibroblastic and smooth muscle features

Back 8

Myofibromatosis

Front 9

Local irritation, common in teens/adults, gingiva most common site, red/highly vascular mass, rapid growth, highly vascular proliferation that looks like granular tissue

Back 9

Pyogenic granuloma

Front 10

~ pyogenic granuloma, with ulcerated surface

Back 10

Peripheral giant cell granuloma, any age

Front 11

Tumorlike growth of gingiva, incisor/cuspid region, forms bone

Back 11

Peripheral ossifying fibroma

Front 12

Not a true neoplasm, reactive hyperplasia of nerve elements b/c damage, small, smooth surface, pink, painful, mental foramen most common location

Back 12

Traumatic neuroma (amputation neuroma)

Front 13

Reactive lesion, <3s face, smooth surface dome, painless, msot frequently on hard palate/maxillary labial mucosa, well circumscribed, **more definite palisading and Verocay bodies typical of Antoni A tissue not seen*, positive for S-100

Back 13

Palisaded encapsulated neuroma

Front 14

Solitary, slow growing mass, encapsulated, tongue = most common oral location, sometimes seen w/ NF, FOM, Antoni A, Antoni B, positive for S100

Back 14

Neurilemoma(Schwannoma)

Front 15

Benign tumor that has Schwann, perineural, neurites. Solitary neoplasm or in association with NF. NONENCAPSULATED (unlike neurilemoma)

Back 15

Neurofibroma

Front 16

Multiple neural tumors, type 1 von recklinghause disease of skin, cafe au lait, lisch nodules, S100 positive

Back 16

Neurofibromatosis

Front 17

Tumors or hyperplasias of neuroendocrine tissues, pheochromocytomas/medullary thyroid carcinoma , autosomal dom, RET protooncogene on chromosome 10, oral mucosal neuromas = first sign, pheochromocytomas 50% patients, development of medullary carcinoma of thyroid gland. Elevated calcitonin, VMA (neural crest origin)

Back 17

MEN 2B - multiple endocrine neoplasia type 2 B

Front 18

Rapidly growing mass of anterior maxillary alveolar ridge, tumor has melanin, destruction of underlying bone

Back 18

Melanotic neuroectodermal tumor of infancy

Front 19

Loves tongue, from Schwann or undiff. mesenchymal cell, slow growing nodular mass, syncytial apperance

Back 19

Granular cell tumor

Front 20

Rare, benign tumor on alveolar ridge of newborns, NO PEH!

Back 20

Congenital epulis

Front 21

Numerous plump endothelial cells, indistinct vascular lumina, involutes, becomes cavernous

Back 21

Hemangioma

Front 22

Hemangiomatosis involving face, oral mucosa, eyes, meninges. Skin/mucosal lesions on distribution of trigeminal nerve. *Gyriform intracranial calcifications, tram-line/railroad tracks**, gingival hyperplasisa

Back 22

Sturge-Weber angiomatosis

Front 23

Tumor only in nasopharynx, locally destructive/aggressive, ADOLESCENT BOYS

Back 23

Nasopharyngeal angiofibroma

Front 24

Loves head and neck, benign tumor of lymphatic vessels, most common site = anterior 2/3rds of tongue, pebbly surface, RBCs

Back 24

Lymphangioma

Front 25

Variety of lymphangioma occuring in neck

Back 25

Cystic hygroma

Front 26

Benign tumor, skeletal muscle origin, loves head and neck

Back 26

Rhabdomyoma

Front 27

Remember osseous and cartilagenous choristoma

Back 27

ok

Front 28

Sarcoma w/ fibroblastic histiocytic features, MOST COMMON SOFT TISSUE SARCOMA IN ADULTS, spindle cells with storiform growth pattern, nuclear pleomorphism, atypical mitotic figures

Back 28

Malignant fibrous histiocytoma

Front 29

Second most common soft tissue sarcoma in adults, normal in color or yellow, loves head and neck

Back 29

Liposarcoma

Front 30

Principal malignancy of peripheral nerve origin, 50% in patients with NF, widening of mandibular canal or mental foramen

Back 30

Malignant peripheral nerve sheath tumor

Front 31

Neoplasm upper nasal vault, most common symptoms = nasal obstruction, epistaxis, pain

Back 31

Olfactory neuroblastoma

Front 32

Rare malignancy of vascular endothelium, vascular tumors w/ microscopic features btwn hemangiomas and angiosarcomas.

Back 32

Hemangioendothelioma

Front 33

Cutaneous angiosarcomas of head and neck, elderly patients, mandible most common site

Back 33

Angiosarcoma

Front 34

KSHV-HHV8, classic, endemic, AIDS, iatrogenic

Back 34

Kaposi's sarcoma

Front 35

Malignant neoplasm of smooth muscle origin, smooth muscle cells lining small blood vessels, 50% oral cases in jawbones

Back 35

Leiomyosarcoma

Front 36

Most common soft tissue sarcoma in kids, H&N most common site

Back 36

Rhabdomyosarcomas

Front 37

PAS positive, diastase resistant crystals, large polygonal cells arranged around central alveolar spaces

Back 37

Alveolar soft-part sarcoma

Front 38

Most common site for oral soft tissue metastases? Second most common site?

Back 38

Gingiva.Tongue

Front 39

Prostate cancer metastasis?

Back 39

Love BONE (hate soft tissue), radioopaque

Front 40

Malignant neoplasm mucous + squamous cells, one of the most common salivary gland malignancies, PAROTID GLAND, PALATE, mucous cells, squamous cells, +/- cystic spaces, graded based on various features, swelling over ramus anterior to ear, angle of mandible

Back 40

Mucoepidermoid carcinoma

Front 41

Malignant neoplasm of mucous and squamous cells, in the jaw, molar/ramus, radiolucent, well or ill-defined, unerupted tooth

Back 41

Intraosseous mucoepidermoid carcinoma

Front 42

Malignant neoplasm of serous acinar cells, low grade, parotid, slow growing. Abundant granular basophilic cytoplasm.

Back 42

Acinic cell adenocarcinoma

Front 43

Malignant transformation of epithelial component of PA, long standing untreated PA, 15 y/o, parotid, long standing mass, h/o rapid growth. Malignant EPITHELIAL component, areas of typical PA

Back 43

Carcinoma ex PA

Front 44

Malignant neoplasm, ductal epithelial and myoepithelial cells, high grade, minor salivary gland, PALATE, slow growing, pain common, FACIAL NERVE PARALYSIS, ductal epithelial and myoepithelial cells, perineural invasion, SWISS CHEESE

Back 44

Adenoid cystic cell carcinoma - cribriform

Front 45

Malignant neoplasm of ductal epithelial cells, minor glands, slow growing painless, ductal epithelial cells/TARGETOID pattern, polymorphous growth pattern, basophilic/mucoid stroma, perineural invasion

Back 45

PLGA - polymorphous low grade adenocarcinoma

Front 46

Benign mixed tumor, most common salivary gland tumor, swelling over ramus anterior to ear, angle mandible, slow growing. Ductal epithelial cells, myoepithelial cells, CHONDROMYXOID STROMA

Back 46

Pleomorphic adenoma

Front 47

Benign neoplasm of oncocytes, slow growing, oncocytes, central nuclei, clear cells

Back 47

Oncocytoma

Front 48

Metaplastic proflieration of oncocytes, oncocytic metaplasia of ducts/acinar cells

Back 48

Oncocytosis

Front 49

Benign neoplasm of ductal epithelium, 2ndary formation LYMPHOID TISSUE, 2nd most common benign parotid tumor, bilateral, male smoking 8x risk. Oncocytic ductal epithelium, bilayered arrangement surrounding cystic spaces, papillary infoldings, stroma w/ prominent lymphoid component

Back 49

Warthin tumor

Front 50

Benign neoplasm of ductal epithelial cells, upper lip, slow growing, freely movable, mistaken for mucocele, columnar/cuboidal cells, long ducts, loose/watery stroma

Back 50

Canalicular adenoma

Front 51

Benign neoplasm of ductal epithelial + myoepithelial cells, slow growing, hereditary, multiple in parotid. Islands/cords epithelial cells, JIGSAW PUZZLE surrounded by pink hyaline material

Back 51

Membranous basal cell adenoma

Front 52

TRUE developmental cyst, ~mucocele, eosinophilic cytoplasm

Back 52

Salivary duct cyst

Front 53

Non-inflammatory disorder of parotid glands, enlargement, underlying systemic problem, swelling of parotid region

Back 53

Sialadenosis