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9 Cards in this Set
- Front
- Back
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what is innate immunity?
components? |
defense mechanisms present before infection
epithelial barriers, phagocytes, NK cells, C', TLRs |
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what is adaptive immunity?
2 main types? which cells mediate each? |
stimulated by microbes, recognized Ags
CMI – T lymphocytes humoral – B cells/Abs |
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what makes up the TCR?
what is it complexed with? what us the usefulness of TCR gene rearrangements? |
TCR has variable and constant regions
constant is w/ CD3 & ζ chain dimer; involved in signal transduction, not Ag binding can classify lymphoid malignancies •polyclonal = non-neoplastic •monoclonal = neoplastic |
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MHC class for CD4 & CD8
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CD4 = T helper cell
binds MHC class II CD8 = cytotoxic T cell binds MHC class I |
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what do B cells become after antigen exposure? what do they secrete?
what is the Ag-binding component on B cells? what is the usefulness of rearranged Ig genes on B cells? |
plasma cells – secrete immunoglobulin
antigen binding component is IgM molecular maker of B cell lineage CD19,20 classify malignancies CD21 is C' receptor; binds EBV |
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what are the 2 types of dendritic cells?
how do they function? |
•interdigitating
•follicular (in lymphoid follicles) both function as APCs |
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what innate ability do NK cells have?
what are the 2 CD markers? how does 1 of them function? what 2 receptors regulate NK cells? what do NKs secrete? |
•can lyse tumor cells, virally infected, and some normal cells w/o previous sensitization
•CD16 & 56 •CD16 = Fc receptor or IgG - allows NK cells to lyse IgG-coated target cells •activating & inhibitor receptors •NKs secrete cytokines |
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what is the main fxn of histocompatability molecules?
what chromosome are they on? name? what are the 3 categories of the HLA system? |
•bind peptide fragments of foreign proteins for presentation to Ag-specific T cells
•located on chromosome 6, called MHC cluster or HLA (human leukocyte antigen) class I = HLA-A, HLA-B, HLA-C class II = HLA-D class III = complement |
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what are the 3 categories of diseases assoc. w/ HLA?
wht is the best-known disease association? |
•inflammatory diseases
•inherited errors of metabolism •autoimmune diseases HLA-B27 = ankylosing spondylitis |
