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67 Cards in this Set

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Foreign body granulomatous reaction to lipid of meibomian glands or Zeis glands
Chalazion
What is considered the "foreign body" in Chalazion
lipid excreted from meibomian/zeis glands
Chalazion: histology
granuloma, giant cells, lymphocytes, plamsa cells and PMNS
waxy, raised nodules with umbilicated center
Moluscum contagiosum
soft, yellowish plaques on medial aspect of eyelids
xanthelasma
xanthelasma: association
hyperlipidemia
xanthelasma: histology
foamy cells in superficial dermis
Touton giant cells
Juvenile xanthogranuloma
yellow-orange skin nodules in children
Juvenile xanthogranuloma
why are the lesions in Juvenile xanthogranuloma yellow
vascular
spontaneous, non-traumatic hyphema (blood in anterior chamber) in children
Juvenile xanthogranuloma
T/F: most nevi of the eyelids are congenital
F: most are acquired
MC malignant tumor of the eyelid
BCC
Where does BCC appear with respect to the eyelid
Lower>medial>upper
raised, firm nodule with "pearly" borders on upper eyelid
BCC
Nodular BCC histology
nests and cords of proliferating epidermal basal cells
T/F BCC mets to lung
false, it is rare for BCC to met
BCC: tx
complete resection
carcinoma that mimics chalazium
sebaceous carcinoma
Sebaceous carcinoma: who
elderly
Sebaceous carcinoma: where
meibomian, zeis or glands associated with caruncle
tumor of zeis glands that grows in nests with central necrosis. May be solid or papillary
sebaceous carcinoma
fungating mass on eyelid with keratin on surface
SCC
T/F: SCC mets to lymph nodes
T
only disease of the conjunctiva
benign ocular cicatricial pemphigoid
benign ocular cicatricial pemphigoid: who
elderly
adhesions (symblepharon), entropion(eyelid turned inward), trichiasis, corneal scarring
benign ocular cicatricial pemphigoid
5 layers of the cornea
epithelium, bowman's, stroma, descements, endothelium
embryologic origin of cornea
neural crest
cause of corneal edema
loss of endothelial cells
The number of endothelial cells in the cornea decreases with …
age
who is most suceptible to corneal infection
those who wear contact lenses and don't use sterile solutions
inflammation of cornea
acanthamoeba keratitis
star-shaped cyst, ring infiltrate, not a lot of inflammatory cells
acanthamoeba keratitis
4MC indications for corneal transplant
aphakic/pseudophakic bullous keratopathy, Fuchs dystrophy, keratoconus and graft failure
55yo female with cloudy cornea and corneal edema
fuchs endothelial dystophy
guttata, thickened Descement's membrane, loss of endothelial cells
fuchs endothelial dystophy
Keratoconus may be associated with…
atopy, Downs, Marfans
bilateral central ectasia of cornea that produces myopia and irregular astigmatism
keratoconus
keratoconus: early histo changes
breaks in epitheliam BM and Bowmans, central stromal thinning, anterior stromal scarring
fleisher ring
keratoconus
munson's sign
keratoconus
Intraocular neuroblastic tumor
retinoblastoma
Intraocular melanocytic tumor
malignant melanoma of the uvea
MC tumor to eye
mets (esp to choroid) from BC,lung, leukemia
MC intraocular malignancy of childhood
retinoblastoma
retinoblastoma: uni or bilateral
33% bilateral
Leukocoria
retinoblastoma
retinoblastoma: gene
chromosome13 tumor suppressor
round, oval or spindle-shaped nuclei; hyperchromatic, necrosis, calcification, Flexner-Wintersteiner rosettes
retinoblastoma
Homer Wright rosettes
retinoblastoma, neuroblastoma or medulloblastoma
what's in the lumen of homer wright rosettes
eosinophilic cytoplasm
Most important risk/prognostic factor for retinoblastoma
extraocular extension
MC primary intraocular tumor of adults
malignant melanoma of the uvea
melanoma of the uvea: who
53yo blue-eyed Europeans
melanoma of the uvea: MC location
choroids
melanoma of the uvea: clinical presentation
visual loss, glaucoma, inflammatory signs mimicking endophthalmitis
melanoma of the uvea: prognostic factors
size
cell type
melanoma of the uvea: cell types
spindle cell
epithelioid cell
mixed cell
Do melanomas of the uvea met via lymphatic or hematogenous spread
hematogenous to liver. the uvea and orbit lack lymphatics.
MC primary malignant orbital tumor of childhood
rhabdomyosarcoma
sudden proptosis in medial, inferior or posterior quadrant
rhabdomyosarcoma
rhabdomyosarcoma: 3 histologic growth patterns
embryonal(most common)
alveolar
differentiated
spindle cells are arranged ina loose syncytium with occasional cells bearing cross-striations; desmin+
rhabdomyosarcoma
rhabdomyosarcoma: 5yr survival
92%
Optic nerve atrophy: etiology
ascending atrophy: loss of retinal ganlion cells b/c of glaucoma/infarction
descending: pathology in cranial cavity or orbit
large cystic spaces containing mucopolysaccharide material posterior to lamina cribrosa
cavernous optic atrophy of schnabel