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36 Cards in this Set
- Front
- Back
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what are superantigens
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bind to MHC II outside of usual area like staph
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what is type I sensitivity
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immediate hypersensitivity
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what Ig is involved in type I
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IgE
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what are the mediators of type I sensitivity
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histamine
leukotrienes |
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what are examples of type I
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seasonal rhinitis
astham anaphylaxis hives diarrhea hay fever |
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what is type II
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antibody dependent cytotoxicity
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what triggers type II
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when antibodies attach to invidiviual cells like RBC and so surfaces with solid tissue and acitvate completlemtn
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what is involved in the mechanism of type II
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MAC
cell l ysis cell opsoniztion and phagocytosis |
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what are exampels of type II
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transfusion
hemolytic disease of the newborn drug reaction like PCN p vulgaris mysanthenia gravis graves |
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what goes on in myasthenia gravis
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anti ACh
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what goes on in graves
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anti TSH
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what is type III
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immune complex mediated
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is type three normal
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sometimes in infections there must be a good balnce between the antigen conc and the antibodies
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what is an example of type three
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arthritis
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what is type IV
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cell mediated
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what are examples of type IV
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tb virus fungi protozoa parasites
injury mediated by sensitized T contact dermatitis delayed type tubercllin hypersensitivy |
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which type is involve din tissue rejection
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type IV
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what are the types of rejection in type IV
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hyepracute
acute chronic |
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what is the fundamental dfect in lupus
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failure to maintain self tolerance
ab against tissues |
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what re the contributory factors to SLE
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genetic
HLA DQ Environemtnal like female sex hormones drugs and UV light |
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what are the primary targets of lupus
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skin
kedneys serosal membranes joints heart |
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what are teh main clniical manifestations of SLE
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hemotagoloic
arthritis skin fever fatiuge |
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what are severl diagnostic criteria for SLE
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malar rash
discoid rash photosensitivity oral ulcers arthritis blood disorder serositis |
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how is SLE diagnosed
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4 of 11
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what are the treatments for SLE
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corticosteroids
immunosuppressive |
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what are complications of corticosteroids
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acne
hirsuitism thin skin obesity osteoporosis buffalo hump cataracts glaucoma DM impotance metnrual disorders moon face opportunitistic infections |
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RA occurs in ____ arthritis pattern
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symmetric
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what ar ethe joints usually affected by SLE
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ankels
knees wrists elbow shouldrs |
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what are the symptoms of RA
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arthritis
general malaise weakness low grade fever raynauds extraarticular manifestations |
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what is raynauds
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episodiec digital ischemia with blanching then darkening of fingers and toes
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what is HLA risk
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HLA DR4 or DR1
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what may cross react leading to RA
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epstein barr
cytomegaolo mycoplasma |
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how is RA diagnosed
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4 of 7
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what are the criteria for diagnosing RA
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SRRAMA
serum r factor rheumatoid nodules radiography for bony erosion arthritis in 3 joints arthritis in hands morning stiffness for one hour plus |
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waht is the lfie expectancy reduction with RA
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3 to 7 years
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what are treatments of RA
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corticosteroids
immunosuppressive therapies |
