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14 Cards in this Set
- Front
- Back
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What is the most common cause of cell injury?
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Hypoxia
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What are 3 causes of hypoxia?
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Ischemia (loss of blood supply)
Dec O2 (heart failure) Dec O2 carrying capacity (anemia,CO poisoning) |
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What kind of damage is caused by most types of cell injury?
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Mitochondrial damage
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What are the results of mitochondrial damage?
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Reduced ATP production, cytochrome C leakageactivates apoptosis
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What causes an initial increase in cellular Ca 2+?
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Influx, release from ER
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What causes a sustained inc in cellular Ca2+?
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Inc membrane permeability
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What does increased cytosolic calcium result in?
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Enzyme activation
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What is a frequent cause of ATP depletion?
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Hypoxia
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What type of injury occurs at low levels of ROS?
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Mutagenesis, carcinogenesis
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Intermediate levels?
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Apoptosis
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High levels?
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Necrosis
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T/F—Following reversal of ischemia (reperfusion), there is further cell death.
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True.
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What is the most common cause of cell injury?
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Hypoxia
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What is the most common cause of cell injury?
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Hypoxia
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