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5 Cards in this Set
- Front
- Back
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What are the locations and significance of solitary plasmacytoma?
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• Nose, outside bone is curable by surgery in nose
• Localized tumor of plasma cells;; may occur in bone marrow; may be extraosseous |
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What is the frequency and significance of MGUS?
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• Precancer for myeloma, don't know when or if they'll have multiple myeloma
• Extremely Common (5%) • Can't have bone lesion, can’t have anemia or renal disease or any other criteria..only thing is monoclonal immunoglobulin • MGUS=monoclonal gammopathy of undetermined significance • M protein is asymptomatic individual: no other evidence of myeloma (diagnosis of exclustion);; incidence=most common monoclonal gammapathy |
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What are the clinical features and neoplasm related to Waldenstrom's macroglobulinemia/
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• Lymphoplasmocytic lymphoma
• Nodal, doesn't cause punched out bone lesion • Protein is monoclonal IgM • Problem is Hyperviscosity and cryoglobulin (cold) • Causes headache, platelet dysfunction, abnormal bleeding • Death in 4 years, it's incurable • Bleeding;; cryoglobulinemia (Raynauds phenomenon) |
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What is the defining cell of Hodgkin lymphoma? Recognize its morphology.
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• Reed-Sternberg cells (owls eye nuclei);; cross eyed (cell w/ two nuclei) cd15:30 + in everything but lymphocyte predominant type
• Hodgkins lymphoma is nodal |
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What are the peak age and general clinical findings of Hodgkin lymphoma?
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• Teens through 30, peak age= 32 (common);
• nontender enlarged lymph nodes • most common is Horse collar, midaxillary then mediastinal • Stage with ann arbor • EBV implicated; RS cell produces cytokines; • Enlarged lymph nodes w/wo systemic syndromes; cervical node enlargement="horse collar"; cervical then axilla then inguinal; medistinal=nodular sclerosing; generalized pruritis; bone marrow pain late; cutaneous anergy; A=absent, B=present and poorer prognosis |
