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48 Cards in this Set

  • Front
  • Back
Episodic dysphagia
w/GERD, GVHD, blistering skin dz
esophageal web
complic of esophageal web
postcricoid CA
Patterson-Brown Kelly or Plummer-Vinson Syndrome
esoph web
progressive dysphagia,
caused by severe esoph injury w/inflam scarring, as from GERD, radiation, scleroderma (scarring), or caustic injury
esophageal stenosis (stricture)
what causes esophageal stenosis (stricture)
severe esoph injury w/inflam scarring, as from GERD, radiation, scleroderma (scarring), or caustic injury
MC motility d/o
achalasia
progressive dysphagia
*achalasia (classic Sx!)
also, esoph stenosis/stricutre
bird beak appearance
achalasia
assoc w/Chaga's Dz
achalasia

(Chaga's Dz caused by T. cruzi-->destroy myenteric plexus of esoph)
*1. non-relaxing LES
2. aperistalsis
3. incomplete relax of LES
achalasia
absent myenteric ganglia
achalasia
complic of achalasia
sq cell CA
inc w/positions favoring reflux (bending fwd, lying supine) & obesity
hiatal (diaphragmatic) hernia
bell-shaped dilation
hiatal (diaphragmatic) hernia
hiatal (diaphragmatic) hernia is assoc w/what?
GERD
mass in neck
Zenker esoph diverticula
nocturnal regurg
epiphrenic esoph diverticula
where is zenker diverticula?
above UES
where is epiphrenic diverticula?
above LES
massive hematemesis in alcoholics
mallory weiss tear
where are mallory weiss tears?
on both sides of GEJ
what causes esoph varicies
portal HTN d/t alcoholic cirrhosis
-->increased pressure in the esophageal plexus produces dilated tortuous vessels, "varices"
what layer are esoph varicies in?
submucosa
what do most ppl w/cirrhosis die from?
ruptured esoph varicies
how Tx esoph varicies?
endoscopic injection of thrombotic agents ("sclerotherapy") or balloon tamponade is usually req'd to stop bleeding
Dysphagia
Heartburn
Regurgitation
GERD
what causes esophagitis
Reflux of gastric contents into the lower esophagus
tobacco exposure inc risk of
GERD
sq cell CA
MCC of GERD
incompetent LES
mmorphological features of GERD
1.inflam cells (PMNs, lymphs, eos) in sq epi layer
2. basal zone hyperplasia
3.elongation of lp papillae
elongation of lp papillae
GERD
basal zone hyperplasia
GERD
Red, velvety mucosa
Barrett
Definitive Dx of Barrett's
intestinal goblet cells
imm-s increases risk of
infectious esophagitis
punched out ulcer
HSV, assoc w/infectious esophagitis (imm-s)
linear ulceration
CMV, assoc w/infectious esophagitis (imm-s)
gray-white (like oral thrush) pseudomembranes
candidiasis, assoc w/infectious esophagitis (imm-s)
how do adults get chemical esophagitis
1.suicide attempt
2. anticancer therapy
3.uremia
what do you see grossly in chemical esophagitis?
erthema and edema, sloughing of the mucosa (acid), or outright necrosis of the entire esophageal wall
Most common are benign tumors of smooth muscle origin
leiomyoma
what is leiomyoma
MC benign tumors of smooth muscle origin
progressive dysphagia and wt loss
sq cell CA
what inc risk of sq cell CA
SYNERGISTIC effect of tobacco and alcohol
carcinoma in situ
sq cell CA
where does sq cell CA occur?
upper & middle 1/3 of esoph
what is precursor to adenocarcinoma?
Barretts
where does adenocarcinoma of esoph occur?
lower 1/3 of esoph