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14 Cards in this Set
- Front
- Back
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SIS
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protooncogene=B-PDGF
astrocytoma, osteosarcoma |
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ERB-B2
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protooncogene=tyrosine kinase growth factor receptor
Breast, ovary, gastric Herceptin |
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C-kit
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protooncogene=cytokine/ growth factor receptor
GIST Gleevec |
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Ras
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protooncogene=G protein
pancreas, lung, colon |
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C-abl
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protooncogene=tyrosine kinase (not receptor)
CML, ALL Gleevec |
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Myc
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protooncogene=transcription factor
translocation Myc-c=burkitt lymphoma, EBV Myc-n= neuroblastoma |
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Cyclin D1
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protooncogene=cell cycle regulator
mantle cell lymphoma |
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APC
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tumor supressor-decreases B catenin
FAP, pancrease |
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Rb
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tumor supressor=binds E2F, blocks G1=>S
retinoblastoma |
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p53
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tumor supressor=blocks G1=>S
Li-fraumeni-many cancers |
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BRCA 1, 2
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tumor supressor=DNA repair
breast, ovary |
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BCL-2
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protooncogene= anti-apoptotic
lymphoma |
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HNPCC
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mismatch repair, autosmal dominant
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Xeroderma pigmentosum
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nucleotide excision repair
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