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56 Cards in this Set

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Type IV hypersensitivity


Mediated by what?

T-cell mediated

Type IV hypersensitivity


Mediated by what cell?

T-cell mediated

Type IV hypersensitivity


Mediated by what?



___- cell __________

T


mediated

Type IV hypersensitivity



Mediated by what?

T-cell mediated

Type IV hypersensitivity


T-cell mediated



How many mechanisms of T cell function that lead to tissue injury?

2

Type IV hypersensitivity


__- cell mediated



There are


_ Mechanisms of _ cell function that lead to tissue ____

T


2


T


injury

Type IV hypersensitivity


T-cell mediated



There are


2 __________ of T cell function that lead to ____ injury

mechanisms


tissue

Type IV hypersensitivity



2 mechanisms of T cell function that lead to tissue injury



List

Delayed hypersensitivity


Direct Cell cytotoxicity

Type IV hypersensitivity



_______________ of _ cell function that lead to tissue _________



Delayed hyper________


Direct Cell cyto____________


2 mechanisms


T


injury



hypersensitivity


cytotoxicity

Type IV hypersensitivity



2 mechanisms of T cell function that lead to tissue injury



Delayed hyper__________


Direct Cell cyto__________

sensitivity


toxicity

Type IV hypersensitivity



2 mechanisms of T cell function that lead to tissue injury



Delayed ____________


Direct Cell ___________

hypersensitivity


direct


cytotoxicity

Type IV hypersensitivity



2 mechanisms of T cell function that lead to tissue injury




___________hypersensitivity


________ Cell cytotxicity

delayed


direct

Type IV hypersensitivity



2 mechanisms of T cell function that lead to tissue injury



____________ hypersensitivity


Direct __________ cytotxicity

Delayed


cell

Type IV hypersensitivity



2 mechanisms of T cell function that lead to tissue injury


Delayed hypersensitivity


Direct Cell cytotxicity


Delayed hypersensitivity


Direct Cell cytotxicity



These are mechanisms of what?


- Cell function


- lead to what?

T cell function


tissue injury


Delayed hypersensitivity



Examples


TB reaction


Persistence of antigen leads to granulomatous inflammation


Delayed hypersensitivity



Examples



_____ reaction


__________ of antigen leads to ________ inflammation

TB


persistence


granulomatous


Delayed hypersensitivity



Example



TB _____


Persistence of ______ leads to granulomatous ________

reaction


antigen


inflammation


Delayed hypersensitivity



Example



___________


_____ of ________ _____ to ________________

TB reaction


persistence


antigen leads


granulomatous inflammation


Delayed hypersensitivity



Example

TB reaction


Persistence of antigen leads to granulomatous inflammation

Type IV hypersensitivity



Name one disease

Type 1 Diabeties mellitus

Type IV hypersensitivity



Name one disease: Type _ diabetes _____

1


mellitus

Type IV hypersensitivity


Name one disease: _____ I ______ mellitus

Type


diabetes

Type I diabetes mellitus

Antigen: pancreatic islet beta cells


Results: diabetes

Type I diabetes mellitus



Type of hypersensitivity


Antigen


Result

Type IV


Pancreatic islet beta cells


Diabetes

Type I diabetes mellitus



Type of Hypersensitivity


Antigen: Pancreatic islet _____ cells


Result: diabetes

IV


beta

Type I diabetes mellitus



Antigen: _______ islet ____ cells


Result:

Pancreatic


beta



diabetes

Type I diabetes mellitus



Antigen: Pancreatic ____ beta _____


Result

islet


cells



diabetes

Type IV hypersensitivity



Notes: Multiple sclerosis

Antigen: protein antigens of CNS myelin


Result: demyelination, paralysis

Type IV hypersensitivity



Notes: Crohns disease

Antigen: unknown, from intestinal microbes


Results: chronic inflammation, fibrosis, stricutre

Type IV hypersensitivity



Notes: Contact dermatitis

Antigen: environmental chemicals


Result: dermatitis (versicular)

Type IV hypersensitivity



Notes: Rheumatoid arthris

An autoimmune disease


Antigen: unidentified antigen in synovium


Systemic, chronic inflammatory disease


Principle target: joints


Can get soft tissue and parenchymal rhematoid nodules

Immune diseases



Two category

Hypersensitivity


Immune deficiency disease

Immune deficiency diseases



Categorization

Can be primary genetic disease or secondary diseases.

Immune deficiency diseases



Category



Can be ______ genetic disease or _____ diseases.

primary


secondary

Immune deficiency diseases



Category



Can be primary ______ disease or ______ disease

genetic


secondary

Immune deficiency diseases



Category



Can be _________ genetic ____ or ________

primary


disease


secondary


disease

Immune deficiency diseases



Category



Can be _____________ or _____________

primary genetic disease


secondary disease

Immune deficiency diseases



Category

Can be primary genetic disease or secondary disease

Immune deficiency diseases



Those afflicted are subject to increased susceptibility to __________

infections

Immune deficiency diseases



Those afflicted are subject to increased ________ to infection

susceptibility

Immune deficiency diseases



Those afflicted are subject to ______ susceptibility to _______

increased


infection

Immune deficiency diseases



Those afflicted are subject to increased susceptibility to infections



Notes

IgG phagocyte cell deficiences - pyrogenic bacteria



Cell mediated: viruses, fungi, and intracellular bacteria

Primary deficiencies



Cause

Genetic

Primary deficiencies



Diseases



List

X-linked agammalglobuniemia (Bruton disease)


DiGeorge Syndrome

Primary deficiencies



Diseases



_-linked agammalglobuniemia (Bruton _______)


DiGeorge __________



X


disease


syndrome

Primary deficiencies



Diseases



__________ agammalglobunie___ (________ disease)


DiGeorge ____________


x-linked


mia


Bruton


syndrome

Primary deficiencies



Diseases



___________ agammalglobu__________ (___________)


Di__________ Syndrome


X-linked


niemia


Bruton disease


George

Primary deficiencies



Diseases



X-linked _______globuniemia (________disease)


_____ George Syndrome


agammal


Bruton


Di

Primary deficiencies



Diseases



X-linked __________ globu________ (Bruton ______)


____________ Syndrome


Agammal


niemia


disease


Digeorge

Primary deficiencies



Diseases



____________ agammal____niemia (__________disease)


_____________ Syndrome


X-linked


globu


Bruton



DiGeorge

Primary deficiencies



Diseases



_-linked ___________globu_________ (_______ disease)


__________Syndrome


X


agammal


niemia


Bruton


Digeorge

Primary deficiencies



Diseases



X-linked _______________ (Bruton disease)


DiGeorge Syndrome


agammalglobulniemia

Primary deficiencies



Diseases



___________________ (________disease)


___________ Syndrome


X-linked Agammalglobuniemia (Bruton)


DiGeorge

Primary deficiencies



Diseases



________________ (________________)


________________



X-linked agammalglobuniemia (Bruton disease)


DiGeorge Syndrome


Primary deficiencies



Diseases



X-linked agammalglobuniemia (Bruton disease)


DiGeorge Syndrome