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Notes: Repair

Restoration of tissue architecture and function after injury

Notes


Regeneration vs. Healing

Regeneration


Ability of tissue to replace itself



Healing


Involves laying down of new connective tissue


Often involves scar formation

Notes


Healing

Begins with apperance of granulation tissue


- Grossly - pink, soft and granular


- Histiologically - fibroblasts, new capillaries and loose appearing connective tissue



Ends with scar formation


- More dense fibrous tissue

Cell proliferation


Learning objective

Know different types of tissues (proliferative capacities)

How many types of tissues in cell proliferation?

3

3 types of tissues in cell proliferation


Categorization is based on what?

proliferative capacities

3 types of tissues in cell proliferation


List

Labile cells/tissues


Stable cells/tissues


Permanent cells/tissues

3 types of tissues in cell proliferation



Labile cells/_____


Stable ______/tissues


Permanent cells/_______

tissues


cells


tissues

3 types of tissues in cell proliferation



La_____ (substance produced by liver) _____/tissues


Stable cells/_______


______________ (forever) _____/tissues

Labile


cells


tissues


permanent


cells

3 types of tissues in cell proliferation



La______ _________


Stable __________


___________ ____________

bile


cells/tissues


cells/tissues


permanent cells/tissues

3 types of tissues in cell proliferation



_______ cells/tissues


S______________ cells/tissues


___________ cells/tissues

Labile


Stable


Permanent

3 types of tissues in cell proliferation



________ cells/tissues


___________ cells/tissues


___________cells/tissues

labile


stable


permanent

3 types of tissues in cell proliferation

Labile cells/tissues


Stable cells/tissues


Permanent cells/tissues

3 types of tissues in cell proliferation



_______________


Stable cells/tissues


Permanent cells/tissues

Labile cells/tissues

Labile Cells/Tissues



Definition

Continuously dividng tissues

Continuously dividng tissue


aka

Labile cells/tissues

Labile cells/tissues


Definition: ____________ dividing _______ (cells/tissue)

continuously


tissues

Labile tissues


Definition: ___________ dividing _______

continuously


tissues

Labile cells/tissues


Definition: Continuously _______ tissues

dividing

Labile tissues/cells


Definition: Continuously ___________ __________

dividing tissues

Labile tissues/Cells


Definition: ______________ tissues

continuously dividing

Labile tissues/cells


Def.

Continuously dividing tissues

Labile tissues



Characteristics

Can easily regenerate

Labile tissues/cells



Definition


Characteristics: Can easily re________

continuously dividing tissues


regenerate

Labile tissues



Definition


Characteristics: Can easily ____________

continuously dividing tissues


regenerate

Labile tissues



Characteristics: Can _____ regenerate

easily

Labile cells/tissues



Characteristics: ______ easily _________



Can


regenerate

Labile cells/tissues



Characteristics: Can __________

easily regenerate

Labile tissues



Characteristics: _____ easily regenerate

Can

Labile tissues



Characteristics

Can easily regenerate

Labile tissues



Definition


Characteristics

Continuously dividing tissues


Can easily regenerate

Labile tissues



Examples

Surface epitheliums


Epithelium of ducts


Hematopoietic tissues

Labile tissues



Characteristics



Examples



Surface epi________s


Epi________ of ducts


Hematopoietic tissues

can easily regenerate


epithelium


epithelium

Labile tissues



Definition



Examples



Surface ______________


___________ of ducts


Hemato________ tissues

Continuously dividing tissues


epitheliums


epithelium


poietic


Labile tissues



Characteristics



Examples



Surface ____________


____________ of ducts


_______________ tissues

Can easily regenerate



epitheliums


epithelium


hematopoietic

Labile tissues



Definition



Examples


__________ epitheliums


Epithelium of _____


Hematopoietic __________

continuously dividing tissues



surface


ducts


tissues

Labile tissues



Examples


___________ epitheliums


_____________ of ____


___________________

surface


epithelium


ducts


heamtopoietic tissues

Labile tissues



Examples

Surface epitheliums


Epithelium of ducts


Hematopoietic tissues

Labile tissues



Definition


Characteristics


Examples

Continuously dividing tissues


Can easily regenerate



surface epitheliums


epithelium of ducts


hematopoietic tissues

Continuously dividing tissues


aka

Labile tissues

3 types of tissues in cell proliferation



Labile tissues


____________________


Permanent cells/tissues

Stable cells/Tissues

Stable Cells/tissues



Characteristics

Retain the ability to proliferate


Capable of limited regeneration

Stable Cells/tissues



Characteristics



Retain the ability to prolif__________


Capable of limited regen_______


proliferate


regeneration

Stable Cells/tissues



Characteristics



Retain the ability to pro____________


Capable of limited re______________

proliferate


regeneration

Stable Cells/tissues



Characteristics



Re______ the ability to p_______________


Cap______ of limited r_______________

retain


proliferate


capable


regeneration

Stable Cells/tissues



Characteristics



Retain the ______ to proliferate


Capable of ______ regeneration

ability


limited

Stable Cells/tissues



Characteristics



_________ the ability to _________


___________ of limited _______________

retain


proliferate


capable


regeneration

Stable Cells/tissues



Characteristics



Retain the _____ to _________________


Capable of ___________________

ability


regenerate


limited regeneration



Stable Cells/tissues



Characteristics



________ the ______ to _____________


______ of _______________

Retain


ability


prolfierate


capable


limited regeneration

Stable Cells/tissues



Characteristics

Retain the ability to proliferate


Capable of limited regeneration

Retain the ability to proliferate


Capable of limited regeneration



Type of cell/tissue

Stable tissue

Stable tissues



Example

Fibroblasts


Endothelial cells


Smooth muscle cells


Parenchymal tissues of most organs

Stable tissues



Characteristics



Example



Fibro________


Endo__________ cells


Smooth _________ cells


Parenchymal tissues of most organs

Retain the ability to proliferate


Capable of limited regeneration



blasts


thelial


muscle

Stable tissues



Example


______blasts


____thelial cells


_______ muscle cells


Parenchymal tissues of most _______


Fibroblasts


Endo


Smooth


organs

Stable tissues



Example



Fi____blasts


____thelial ____


______ muscle ______


Parenchy____ tissues of _______ organs

bro


Endo


cells


smooth


cells


mal


most

Stable tissues



Fi________


____________ cells


Smooth __________ cells


par_______mal _______ of most ______

Fibroblasts


endothelial


muscle


enchy


tissues


organs

Stable tissues



Example


______________


_____________ cells


_________________ cells


____enchy______ __________ of _______________

Fibroblasts


Endothelial


Smooth muscle


par


mal


tissues


most organs

Stable tissues



Example


_______________


_____________________


_______________________


________________________ of _____________

Fibroblasts


Endothelial cells


Smooth muscle cells


Parenchymal tissues of most organs

Stable tissues



Example

Fibroblasts


Endothelial cells


Smooth muscle cells


Parenchymal tissues of most organs

Stable tissues



Characteristics



Example

Retain the ability to proliferate


Capable of limited regeneration



Firboblasts


Endothelial cells


SM cells


Parenchymal tissues of most organs

3 types of tissues in cell proliferation

Labile tissues


Stable tissues


Permanent tissues

3 types of tissues in cell proliferation



Labile tissues


Stable tissues


____________________

Permanent

Permanent tissues/cells



Definition

Terminally differentiated


Non-proliferative in postnatal life

Permanent tissues/cells


Definition



Terminally diff_____________


Non-pro_____________ in postnatal life

differentiated


proliferative

Permanent tissues/cells


Definition



Terminally _________________


Non-____________ in post______ life

differentiated


proliferative


natal

Permanent tissues/cells


Definition



_____________ differentiated


_____-proliferative in ____natal _____

Terminally


non


post


life

Permanent tissues/cells


Definition



_____________ differentiated


Non-________________ in _________________

Terminally


proliferative


postnatal life

Permanent tissues/cells


Definition

Terminally differentiated


non-proliferative in postnatal life

Permanent tissues/cells



Characteristics

May have limited ability to proliferate; but insufficient to regenerate

Permanent tissues/cells


Definition



Characteristics


May have limited ability to pro_____; but insufficient to re___________.

Terminally differentiated


non-proliferative in postnaltal life



proliferate


regenerate

Permanent tissues/cells



Characteristics


May have limited ability to _________; but insufficient to _________

proliferate


regenerate

Permanent tissues/cells



Characteristics


may have ______ ability to proliferate; but ____ to regenerate

limited


insufficient

Permanent tisues/cells



Characteristics



_______ limited ____ to _____, but insufficient to ________.

may have


ability


proliferate


regenerate

Permanent tissues/cells



Definition



Characteristics


May have _____ _____to __________; but _____ to ___________

Terminally differentiated


Non-proliferative in postnatal life



limited ability


proliferate


insufficient


regenerate

Permanent tissues/cells



Characteristics

May have limited ability to prolfierate; but insufficient to regenerate

Permanent tissues/Cells



Definition


Characteristics

Terminally differentiated


non-proliferative in postnatal life



May have limited ability to proliferate, but insufficient to regenerate

Permanent tissues/cells



Examples

Majority of



neurons


and


Cardiac cells

Permanent tissues/Cells



Definition



Examples


Majority of



neu____


car____ cells

Terminally differentiated


Non-proliferative in postnatal cells



neurons


cardiac cells

Permanent tissues/cells



Examples


Majority of


_________ and cardiac ______

Neurons


cells

Permanent tissues/cells



Characteristics



Examples



______ of


Neurons and ______________

May have limited ability to proliferatie; but insufficient to regeneration



Majority


cardiac cells

Permanent tissues/cells



Examples

Majority of


neurons and cardiac cells

Permanent tissues/Cells



Definition


Characteristics


Examples

Terminally-differentiated


Non-proliferative in postnatal life



May have limited ability to proliferatie, but insufficient to regeneration



Majority of neurons and cardiac cells

3 types of tissues in proliferation

Labile tissues/cells


table tissues/cells


Permanent tissues/cells

Stem cells



Characteristics

They are self-renewing



Have asymmetric replication

Stem cells



Characteristics



They are self-re___ing


Have asymmetric repli_____

new


replication

Stem cells



Characteristics



They are self-re_______


Have asymmetric ____________

newing


replication

Stem cells



Characteristics



They are self-_______


Have ________ replication

renewing


asymmetric

Stem cells



Characteristics



They are _____-renewing


Have ____________ replication

self


asymmetric

Stem cells



Characteristics



They are _____________


Have ___________________

self-renewing



asymmetric replication

Stem cells



Characteristics

They are self-renewing


Have asymmetric replication

Stem cells



They are self-renewing


Have ______ replication



Define self-renewing

Can continuously replicate

Stem cells



They are self-renewing


Have asymmetric ___________



Define self-renewing: Can continuously re_____.

replication


replicate

Stem cells



They are self-renewing


Have asymmetric _____________



Define self-renewing: can continuously _________.

replication


replicate

Stem cells



They are self-renewing


Have asymmetric ___________



Self-renewing: ____ continuously _______

replication


can


replicate

Stem cells



They are self-renewing(can __________ replicate)

Continuously

Stem cells



They are self-renewing (Can ___________)

continuously replicate

Stem cells



They are self-renewing



Define self-renewing



Can continuously replicate

Stem cells



They are self-_______


Have asymmetric replication



Define asymmetric replication

renewing



1/2 of progeny remain undifferentiated to self-renew



1/2 of progeny enter differentiation cycle of that tissue

Stem cells



They are self-__________


Have asymmetric replication



Define asymmetric replication




1/2 of progeny remain undiff__________to self-renew



1/2 of progeny enter differentiation cycle of that tissue


renewing


undifferentiated


renew

Stem cells



They are _______-renewing


Have asymmetric replication



Define asymmetric replication



1/2 of progeny remain ____differentiated to ____-renew


_____ of progeny enter differentiation cycle of that tissue

self


un


self


1/2


Stem cells



Have asymmetric replication



Define asymmetric replication


1/2 of progeny remain ___________ to self-____



1/2 of progeny enter ___________ cycle of that tissue

undifferentiated


renew


differentiation

Stem cells



Have asymmetric replication



Define asymmetric replication


_____ of progeny remain undifferentiated to ____________



____ of _______ enter differentation _____ of that tissue

1/2


self-renew



1/2


progeny


cycle

Stem cells



Have asymmetric replication



Define asymmetric replication


1/2 of progeny ______ undifferentiated to self-renew



1/2 of progeny _____ differentation cycle of that tissue

remain


enter

Stem cells



Have asymmetric replication



Define asymmetric replication


____ of progeny ______ undifferentiated to _____



____ of progeny ______ differentation cycle of that ________

1/2


remain


self-renew



1/2


enter


tissue

Stem cells



Have asymmetric replication



Define asymmetric replication


_____ of _______ remain _________ to ___________



_____ of _____ enter _________ of that _____.

1/2


progeny


undifferentiated


self-renew



1/2


progeny


differentiation cycle


tissue

Stem cells



Have asymmetric replication



Define asymmetric replication


_____ of ________________ to __________



_____ of __________________ of ______


1/2 of progeny remain undifferentiated to self-renew



1/2 of progeny enter differentation cycle of that tissue

Stem cells



Have asymmetric replication



Define asymmetric replication

1/2 of progeny remain undifferentiated to self-renew



1/2 of progeny enter differentiation cycle of that tissue

Stem cells



Asymmetric replication



1/2 of progeny remain __________ to self-renew



1/2 of progeny enter _________ cycle of that tissue


undifferentiated


differentiation cycle

Describe the differentiation process in stem cell

May be specific to tissues (i.e. epitheliums)


or


May be pluripotent


- Embryonic Stem Cells


- Adult of Tissue Stem Cells

Differentiation Process in stem cell



How many options do stem cells have?

2

Differentiation Process in stem cell



_ options


May be specific to _______ (i.e. epitheliums)


or


May be pluriPOTENT


- Embryonic ______ Cells


- Adult of Tissue Stem ______


2


tissue


stem


cells

Differentiation Process in stem cell



2 _______


May be specific to ______ (i.e. epi_______)


or


May be pluri_________


- Embryonic ____________ cells


- Adult of Tissue __________

options


tissues


epitheliums


potent


stem


stem cells

Differentiation Process in stem cell



2 options


May be _________ to tissues (i.e. __________)


or


May be ______potent


- Emb_______ _______


- Adult of __________ Stem Cells

specific


epitheliums


pluri


embryonic stem cells


tissue


Differentiation Process in stem cell



2 options


May be ______ to ____________ (i.e. ___________)


or


May be ______________


- ______________ Stem ______


- ________ of Tissue Stem _________

specific


tissues


epithelium


pluripotent


Embryonic


cells


Adult


cells

Differentiation Process in stem cell



2 options


________specific ____ tissues (______ epitheliums)


or


____________ pluripotent


- Embryonic _____________


- Adult __ Tissue _____________

May be


to


i.e.


maybe


stem cell


of


stem cell

Differentiation Process in stem cell



_ options


_____________ to _________ (i.e. ___________)


or


________________


- _____________________


- _______ of _______________

2


May be specific


tissues


epithelium



maybe pluripotent


Embryonic stem cells


Adult


tissue stem cell

Differentiation Process in stem cell



2 options

May be specific to tissues (i.e. epitheliums)


or


May be pluripotent


- Embryonic Stem Cells


- Adult of Tissue Stem Cells