Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/20

Click to flip

20 Cards in this Set

  • Front
  • Back
What are the components of hemostasis?
Blood vessels
Platelets
Coagulation cascade
What are the major events of blood coagulation?
vesicular constriction
platelet aggregation
fibrin formation
What factors are invloved in the intrinsic pathway of the coagulation cascade?
XII
XI
IX
VIII
What factors are involved in the extrinsic pathway of the coagulation cascade?
VII
What factors are involved in the common pathway of the coagulation cascade?
X
V
II
Thrombin
Fibrinogen
What are the laboratory screening tests of hemostasis?
What condition do these test for?
1. Bleeding time
2. Platelet count
3. Prothrombin time (PT)
4. Partial Prothrombin time (PTT)
What does the bleeding time test measure and what factors does it depend on?
1. Time needed for a standard skin incision to stop bleeding
2. # of platelets and function of platelets
What does the platelet count test measure and what factor does it depend on?
1. # of platelets/unit volume of blood
2. # of circulating platelets
What does the PT test measure and what factors does it depend on?
1. extrinsic and common pathways
2. Fibrinogen and Factors II, V, VII, X
What does the PTT test measure and what factors does it depend on?
1. Intrinsic and common pathways
2. Fibrinogen and Factors II, VIII, IX, X, XI, XII
What are 4 more specific lab tests for Hemostasis?
1. levels of specific clotting factors
2. level of fibrinogen and fibrin split products
3. presence of circulating anticoagulants
4. platelet ftn tests
What are two major categories of bleeding disorders and what are their clinical manifestations?
1. Platelet deficiency- platelet type
2. Derangement of blood clotting- coagulative type
If a patient has prolonged bleeding time, a dec platelet count, and normal PT and PTT tests what disorder might they have?
What are the screening tests and results for Platelet Deficiency?
If a patient has normal platelet count and bleeding time but abnormal PT and PTT what condition might they have?
What are the screening test and results for Derangement of Blood Clotting Disorder?
What are the 5 causes of Thrombocytopenia?
Dec. production
dec. survival
sequestration by spleen
dilutional
qualittive defects in platelet
ftn.
What tests are used clinically to determine thrombocytopenia?
1. dec platelets
2. bleeding time may be abnormal
What causes a dec. in platelet production and what condition does this lead to?
1. bone marrow disease, selective impairment of platelet production, ineffective production of platelets
2. Thrombocytopenia
What causes decreased platelet survival and what condition does this lead to?
1. immunologic destruction and Non-immunologic destruction
2. Thrombocytopenia
What are the clinical features of ITP (idiopathic thrombocytopenia purpura)?
autoimmune
most frequently seen in 20-40
yr. old females
pt's have antiplatelet
antibodies
The spleen is the major site
of platelet destruction
What are the clinical features of TTP (Thrombotic Thrombocytopenia Purpura)?
non-immune disorder
adult female
PENTAD: thrombocytopenia
Fever
*microangiopathic
hemolytic anemia
neurologic symptoms
renal failure