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63 Cards in this Set
- Front
- Back
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DOC for Legionnaires dse
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Erythromycin
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DOC for Neisseria gonorrhoeae
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Ceftriaxone
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Antidote for beta blocker overdose
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Give glucagon
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Antidote for benzodiazepine toxicity
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Flumazenil
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Succinylcholine
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depolarizing neuromuscular blocker
causes fasciculations because it stimulates the nicotinic acetylcholine receptors on skeletal muscle and depolarizes skeletal muscle |
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Nondepolarizing skeletal muscle relaxants
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competitively block the Nm receptors
exhibit flaccid paralysis immediately |
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Dipyridamole
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platelet aggregation inhibitor that inc cAMP levels by inhib cyclic nucleotide phosphodiesterase
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Selegiline
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inhibits degradation of dopamine by MAO type B
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Carbidopa
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inhib dopa decarboxylase
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Bromocriptine, pergolide
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dopaminergic receptor agonists
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Tolcapone
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COMT- catecholamine- inhibitor
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Phase I metabolism and age
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less efficient with age
accomplished largely by cyt P450 |
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Quinidine
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tx ventricular arrhythmias and afib
SE cinchonism- tinnitus, blurred vision, upset stomach, confused delirious behavior |
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Hydralazine
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use to tx for htn
SE include tachycardia, HA, nausea, lupus like syndrome in a slow acetylators |
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Niacin
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tx hyperlipidemia
SE cutaneous flushing and pruritis |
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Spironolactone
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K sparing diuretic, aldosterone antagonist
SE hyperkalemia, gynecomastia |
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Tubocurarine
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skeletal muscle relaxant
produces a lot of histamine release |
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Baclofen
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antispasmodic
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Dantrolene
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tx malignant hyperthermia
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Meperidine
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full mu antagonist
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Phenytoin
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tx grand mal and tonic clonic sz
se diplopia, gingival hyperplasia, hirsutism, nystagmus, sedation, ataxia, enzyme induction |
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Valproic acid
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all sz type, particularly myoclonic and petit mal sz
se gi distress, hepatotox, inhib drug metabolism |
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Ritodrine
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beta 2 agonist
can cause uterine relaxation terbutaline also used |
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Antidote for organophosphate tox
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Atropine
antidote for anticholinesterase tox |
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Tx for pts who ingested methanol or ethylene glycol
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ethanol
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Tx acidosis produced by overdose of TCAs
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Sodium bicarbonate
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DOC for absence seizures
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Ethosuximide
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DOC for status epilepticus
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Diazepam
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Tetracaine
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long duration ester local anesthetic
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Lidocaine
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medium duration amide and antiarrhythmic
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Procaine
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short duration ester
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Bupivacaine
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long duration amide
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Metformin
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dec production of glucose in liver, inc uptake of glucose in liver, no effect on secretion of pancreatic insulin
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Sulfonylureas
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Acetohexamide, chlorpropamide, glyburide, tolbutamide
stimulate secretion of insulin from the pancreas |
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Ammonium chloride
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acidifies the urine
hastens the elimination of weak bases, like dextroamphetamine |
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tx TIAs
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Aspiring
reduces incidence of stroke and death in pts with TIAs |
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Enalapril
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reduces preload and afterload
does not affect inotropic state |
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Cytarabine
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S phase specific
disrupts DNA synthesis |
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Hydroxyurea
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S phase specific
interferes with ribonucleoside diphosphate reductase |
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Apomorphine
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dopamine and opioid agonist
stimulates the chemoreceptor trigger zone in te medulla, induces vomiting |
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Nitroprusside
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very rapid onset of action, dilates arterioles and venules
SE hypotension, accum of cyanide in pts with liver or renal failure |
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Flutamide
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competitive androgen antagonist
tx prostate cancer |
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What do you administer with imipenem
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Cilastin- limits imipenems tox by blocking renal dipeptidase, minimizing accum of nephrotoxic metabolites
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Prolactin secretion inhibited by
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Dopamine
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Non dihydropyridine CCBs
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Verapamil, Diltiazem
binds L type voltage gated ca channels in SA node, AV node and vasc smooth muscle |
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Nitrates
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vasodilates by releasing NO in smooth muscle
inc cGMP and smooth muscle relaxation, dec preload dilates veins>arteries |
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Hydralazine
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peripheral vasodilator, arterioles > veins, reduces afterload
se lupus like syndrome contraindicated in angina/CAD |
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Ticlopidine
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inhibits platelet aggregation by irr blocking ADP receptors
SE neutropenia use with caution in pts that are poor metabolizers of 2C19 |
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Isoniazid
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inhibits mycolic acid synthesis, disrupting bacterial cell wall synthesis
peripheral neuropathy, hepatotox give B6 monitor LFTs on baseline take on empty stomach |
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Ethambutol
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inhibits metabolite synthesis
dec visual acuity contraindicated in optic neuritis |
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Rifampin
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inhibits DNA dep RNA polymerase
red orange body fluids, hepatotox, thrombocytopenia inducer of cyt p450- 3A4 and 2C9 |
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Pyrazinamide
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bacteriostatic or cidal
arthralgia, hyperuricemia, hepatotox |
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Midazolam
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reversibly interacts with GABA, exhibits sedative, anxiolytic amnesic and hypnotic activities
induces general anesthesia, used for endoscopy |
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Thiopental
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potentiates inhib effects of GABA, depresses neuronal activity, short acting barbiturate
SE resp depression, hypotension tx elevated intracranial pressure, gen anesthesia, sz rapid entry into brain, rapid redistribution in tissue and fat |
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Propofol
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potentiates GABA A receptors
global CNS depression general anesthesia less post op nausea than thiopental |
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Ketamine
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produces dissociative analgesia and sedation
SE hypotension, tachycardia, disorientation, hallucinations, vivid dreams |
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Etomidate
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short acting hypnotic
SE myoclonus, N V induction of gen anesthesia |
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Non depolarizing muscle relaxants
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competes with ACh for receptors
-curium SE prolonged apnea, bronchospasm, rare anaphylaxis |
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Depolarizing muscle relaxant
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Succinylcholine
stim motor endplate ACh receptors SE hypercalcemia, hyperkalemia, malignant syndrome |
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Cyclosporine
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inhibits calcineurin to block lymphocyte activation
nephrotox for severe refractory cases of UC, RA, psoriasis, organ transplant rejection |
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Infliximab
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binds and inhibits TNF alpha
SE delayed hs rxns |
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Loperamide
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binds gut wall opioid receptor, inhib peristalsis, inc anal sphincter tone
tx diarrhea |
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Octreotide
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somatostatin analog
inhib GH, glucagon, insulin, LF, VIP tx acute variceal bleeds, acromegaly, VIPoma, carcinoid tumors |
