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30 Cards in this Set
- Front
- Back
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What is MOA of H2 Blockers?
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Reversible block of Histamine H2 receptors to decrease H+ secretion by parietal cells
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What are the indications for H2 blockers?
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peptic ulcer
gastritis mid-esophageal reflux |
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What are the adverse effects of H2 blockers?
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Prolactin release (gynecomastia, decreased libido, impotence in males)
Cimetidine inhibits P450 |
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What are the H2 blockers?
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Cimetidine
Ranitidine Famotidine Nizatidine |
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What is the MOA of PPI's?
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Irreversibly inhibit H+/K+ ATPase in stomach parietal cells
Decreases proton secretion by parietal cells |
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What are the indications for PPI's?
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peptic ulcer
gastritis mid-esophageal reflux Zollinger-Ellison syndrome |
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What are the PPI's?
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omeprazole
lansoprazole |
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What is the MOA of misoprostol?
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PGE1 analog
Increase production and secretion of gastric mucous barrier Decreased acid production |
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What are the indications for misoprostol?
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Prevents NSAID-induced peptic ulcers
Maintenance of a PDA Induce labor |
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What are the adverse effects of misoprostol?
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Diarrhea
Contraindicated in women of childbearing potential Abortion-inducing drug |
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What is the MOA of octreotide?
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Long-acting somatostatin analog
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What are the indications for octreotide?
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acute variceal bleeds
acromegaly VIPoma carcinoid tumors |
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What are the adverse effects of octreotide?
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nausea
cramps steatorrhea |
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What is the MOA of bismuth / sucralfate?
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Bind ulcer Base, providing physical protection
Allows bicarbonate ion secretion to reestablish pH gradient in the mucous layer |
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What are the indications for bismuth / sucralfate?
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increase ulcer healing
traveler's diarrhea |
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What is the MOA of infliximab?
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Monoclonal antibody to TNF
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What are the adverse effects of infliximab?
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Respiratory infection (including reactivation of latent TB)
Fever Hypotension |
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What is the MOA of sulfasalazine?
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combination of sulfapyridine (antibacterial) and 5-aminosalicylic acid (anti-inflammatory) activated by colonic bacteria
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What are the indications for sulfasalazine?
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Ulcerative colitis
Crohn's disease |
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What are the adverse effects of sulfasalazine?
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malaise
nausea sulfonamide toxicity reversible oligospermia |
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What is the MOA of ondansetron?
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5-HT3 antagonist
Powerful central-acting antiemetic |
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What are the indications for ondansetron?
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Control vomiting in patients undergoing chemotherapy and postoperatively
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What are the adverse effects of ondansetron?
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Headache
constipation dizziness |
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What is the MOA of osmotic laxatives?
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Provide osmotic load to draw water out
*Lactulose* treats hepatic encephalopathy: gut flora degrades it into metabolites (lactic acid and acetic acid) that promote Nitrogen excretion as NH4+ |
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What is the indication for osmotic laxatives?
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constipation
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What are the adverse effects of osmotic laxatives?
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diarrhea
dehydration may be abused by bulimics |
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What are the osmotic laxatives?
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magnesium hydroxide
magnesium citrate polyethylene glycol lactulose |
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What is the MOA of metoclopromide?
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D2 receptor antagonist
Increase resting tone, contractility, LES tone, motility Does not influence colon transport time |
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What are the indications for metoclopromide?
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Diabetic gastroparesis
Post-surgery gastroparesis |
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What are the adverse effects of metoclopromide?
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Increased Parkinsonian effects
Restlessness, drowsiness, fatigue, depression, nausea, diarrhea Drug interaction with digoxin AND diabetic agents Contraindicated in small bowel obstruction |
