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24 Cards in this Set
- Front
- Back
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What does the humoral system protect? What cells are involved? What types of infections do they protect from?
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Blood
B cells and neutrophils Bacterial |
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What does Cell Mediated Immunity protect? What cells are involved? What infections does it protect from?
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Tissues
T cells and macrophages Viral, Fungal, Mycobacterial, Protozoan, Parasitic, Neoplasm |
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What are the distinguishing characteristics of DiGeorge Syndrome?
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Third pharyngeal pouch didn't develop
No thyroid Non parathyroids Hypocalcemia - ONLY IMMUNODEFICIENCY WITH ELECTROLYTE PROBLEM - Click and Move!! |
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What 4 diseases have a chromosome 22 deficiency
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DiGeorge
Neurofibromatosis Type 2 CML Ewing's |
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What are the clues for chronic mucocutaneous candidiasis?
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Recurrent candida infections because T-cell can fight everything else EXCEPT candida
Causes chronic fatigue syndrome |
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Why does chronic mucocutaneous candidiasis cause chronic fatigue syndrome?
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Candida feeds on patient's glucose - making patient weak and leaving them in a low energy state
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What are the functions of steroids?
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Kills eosinophils and T cells
Inhibits macrophage migration Inhibits mast cell degranulation Inhibits Phospholipase A Stabilizes the endothelium Catabolic actions: Proteolysis Gluconeogenesis |
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Which steroid is used to treat endometriosis?
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Danazole
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Which steroid is used to enhance surfactant production of baby?
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Betamethasone
Beclomethasone NOW - IM Dexamethasone |
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Which steroid can be used to replace aldosterone?
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Fludrocortisone
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What are the clues for hairy-cell leukemia?
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Fried egg/Sunburst appearance
Tartrate Resistant Acid Phosphatase (TRAP) - positive |
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The majority of leukemias and lymphomas are of what cell type?
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B cell - 98%
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What are the 2 T cell lymphomas? What clue identifies them?
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Sezary (in blood)
Mycosis Fungoides (cutaneous) |
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What is the deficiency that causes SCID?
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adenosine deaminase
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What is the new standard of care for SCID?
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Bone marrow transplant (or pt dies before 2yo)
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What are the clues for Wiscott Aldridge Syndrome?
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Thrombocytopenia
Infections are numerous Eczema X-linked recessive |
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What are the clues for Bruton's agammaglobulinemia?
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Less than 1 year old
B cells don't progress to plasma cells therefore no antibodies are produced B cell count is normal |
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What are the clues for Common Variable Immunodeficiency (CVID)?
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Late onset Bruton's (after 1st year of life)
B cell count is normal |
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What are the two types of plasma cell cancer? Clues?
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Plasmacytoma: One lytic lesion
Multiple myeloma: - multiple lytic lesions - kappa light chains --> Bence Jones proteinuria - IgG --> M-spike - Hypercalcemia - Rouleaux formation |
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What are the clues for Heavy chain disease?
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IgA and multiple myeloma of the GI tract
Causes malabsorption |
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What are the clues for selective IgA def?
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Occurs with Selective IgG2 95% of time
Transfusion anaphylaxis Recurrent mucosal infections |
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What are the clues for Selective IgG2 def?
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Recurrent encapsulated organism infections
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What are the encapsulated organisms? Which is gram +?
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Strep pneumo (gram +)
Salmonella Klebsiella H Influenza B Pseudomonas Niesseria Citrobacter |
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What is Job-Buckley syndrome?
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Red-haired female
IgE only due to cell-signalling defect |
