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19 Cards in this Set

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Interfere w/Microtubule func
Vincristine, Vinblastine
Mitotic arrest in Metaphase
Paclitaxel
Trt Ovary/Brst Cancer
Mitotic arrest in Anaphase
Hyperstabilize microtubules
Dactinomycin
Binds Dbl strnd DNA
Btwn GC pairs (inhib mRNA synth)
Trt Wilms Tumor
Doxorubicin
Intercalate into DNA
Inhib Synth
Tox bc Free radicals
Methotrexate
Trt Leuk/Sarcoma
folic acid antag
Binds DHF Reductase
Can Dev resistnce
Leucovorin
Rescue Bone marrow suppression with Methotrexate
Tumor cells cant take it up
Bleomycin
Frags DNA via O2 radicals
cells accum in G2
w/chromatid brks
Little Marrow Tox
Tamoxifen
Antiestrogen effects
Trt Brst Cancer
Nitrosureas
Carmustine, Lomustine
Trt Brain tumors (cross BBB)
alkylate/crosslink DNA
Req BioActivation
GnRH Analogs
Leuprolide, Goserelin
Act @ Pit to Inhib LH release
So dec Estrog synth by ovary
Trt: Estro-R+ Brst cancer
Cisplatin
Trt Testicular, Lung Carcinoma
crosslink N7 of guanine
Prednisone
Trt CLL, Hodgkins
Apop non-dividing cells
cytarabine
Inhib DNA pol
After Metab Activation
by deoxycytidine kinase
G1 Phase
no drugs
S Phase
Hydroxyurea= inhib ribonuc reductase
5-FU= inhib thymid synth
6-MP= Inhib Pu synth
Methotrexate= inhib DHF reduc
Cytarabine=inhib DNA elong
G2 Phase
Bleomycin=Frag DNA
Etoposide=stabil TopoII &DNA
Late G2/Early M
Vincristine/blastine= bind tubulin
M Phase
Paclitaxel= stabilize microtubules
Vincristine/Vinblastine
Non-Phase specific
wrk @ any phase (inc Go)
More suscep in G1/S
usually @S and progression stopped