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19 Cards in this Set
- Front
- Back
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Interfere w/Microtubule func
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Vincristine, Vinblastine
Mitotic arrest in Metaphase |
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Paclitaxel
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Trt Ovary/Brst Cancer
Mitotic arrest in Anaphase Hyperstabilize microtubules |
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Dactinomycin
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Binds Dbl strnd DNA
Btwn GC pairs (inhib mRNA synth) Trt Wilms Tumor |
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Doxorubicin
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Intercalate into DNA
Inhib Synth Tox bc Free radicals |
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Methotrexate
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Trt Leuk/Sarcoma
folic acid antag Binds DHF Reductase Can Dev resistnce |
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Leucovorin
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Rescue Bone marrow suppression with Methotrexate
Tumor cells cant take it up |
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Bleomycin
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Frags DNA via O2 radicals
cells accum in G2 w/chromatid brks Little Marrow Tox |
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Tamoxifen
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Antiestrogen effects
Trt Brst Cancer |
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Nitrosureas
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Carmustine, Lomustine
Trt Brain tumors (cross BBB) alkylate/crosslink DNA Req BioActivation |
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GnRH Analogs
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Leuprolide, Goserelin
Act @ Pit to Inhib LH release So dec Estrog synth by ovary Trt: Estro-R+ Brst cancer |
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Cisplatin
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Trt Testicular, Lung Carcinoma
crosslink N7 of guanine |
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Prednisone
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Trt CLL, Hodgkins
Apop non-dividing cells |
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cytarabine
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Inhib DNA pol
After Metab Activation by deoxycytidine kinase |
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G1 Phase
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no drugs
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S Phase
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Hydroxyurea= inhib ribonuc reductase
5-FU= inhib thymid synth 6-MP= Inhib Pu synth Methotrexate= inhib DHF reduc Cytarabine=inhib DNA elong |
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G2 Phase
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Bleomycin=Frag DNA
Etoposide=stabil TopoII &DNA |
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Late G2/Early M
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Vincristine/blastine= bind tubulin
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M Phase
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Paclitaxel= stabilize microtubules
Vincristine/Vinblastine |
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Non-Phase specific
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wrk @ any phase (inc Go)
More suscep in G1/S usually @S and progression stopped |
