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30 Cards in this Set
- Front
- Back
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InActivate Na+ chnl
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"PVC"
Phenytoin Valproate Carbamazepine |
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Osteomalacia
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Phenobarbital and Phenytoin
Induce CYP450 Inc Metab of Vit D/K Dec Abs Ca (bone resorp) |
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Baclofen
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GABAb-R link to K chnl
Hyperpol Prvnt release Glut onto a-motor neurons |
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Dantrolene
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Trt Malig Hyperthermia
Trt Neuroleptic Malig Synd |
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NE Reuptake blocked
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Desipramine
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5-HT Reuptake blocked
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SSRIs
Fluox, Fluvox Parox, Citalopram |
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Both NE/5HT blocked
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Imipramine
Clomipramine Venlafaxine |
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MAOI
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Phenel&Trany
No Tyramine foods Inhib MAO-A (so NE&5HT stay arnd) |
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AntiPsycho
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Block D2-R in Mesolimbic
Haloperidol=least sedate (turrets) Clozapine= Trt Neg Symp Chlorpromazine= Prevent N/V |
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Lithium
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ReAbs Inc by HCTZ/Furosemide
Nephrogenic DI If 1st Trimester=Ebsteins (mitral/tricuspid problem) |
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Parkinsons
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L-Dopa= precursor to DA
Carbidopa= inhib decarbox can dec amnt of dopa) Benztropine= Cent Musc block Amantadine=Antiviral release DA Selegiline=MAO-B inhib |
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Cause HyperPRL
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Haloperidol
Reserpine Metoclopramide a-Methyldopa Inhib PRL relase=Bromocrip |
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Ethanol removal
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First=Zero Order (amnt)
Later=First Order (frac) |
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Methanol Tox
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Like in snow storm
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Phentermine
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Dec Appetite
Bc release NE in Hypothal |
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Thiopental
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Poor analgesic
Induction of Anesthesia Shrt duration bc Redeistrib |
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BZ
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Old ppl: Inc halflife
Dec Cl Dec P450 Dec plasma prot Inc R-sens (Inc falls) |
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Glucuronidation
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No dec in old ppl
So use: Oxazepam, Lorazepam |
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Flumazenil
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BZ-R Antag
Trt BZ OD (also precip withdrawl) |
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Buspirone
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Anxiolytic (no addict)
Part Ag @ 5-HT1a Slow onset |
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Naloxone
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iv
For Opiate OD (resp depress) Need Mult Doses (Naltrexone=po) |
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Partial mu Agonists
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Pentazocine
Butorphanol Nalbuphine buprenorphine Get withdrawl/less respir dep |
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No Tolerance w/Opiates
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Constipation
Miosis |
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Diphenoxylate
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Least addictive
Trt Diarrhea |
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MAC
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MAC high=o/g low=potency low
DOESNT affect rate of induction |
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b/g coeffic
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b/g low=poor sol=rapid on/off
Anemics: quicker on/off (less RBC- Sat quicker) |
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Nitrous Oxide
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secondary gas
Pulls Halothane along Quickens onset/offset Diffusional Hypoxemia Rupture TM of N/V after surg |
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Ketamine
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block NMDA glut-R
Dissoc State/PostAnesth halluc Least respir suppress |
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Etomidate
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Inc GABAa-med Cl-conduc
Hyperpol Min effect BP/Respir Myoclonic so Pretrt w/BZ |
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BP/Respir
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Opiate= Dec respir
Ketamine= Inc BP Etomidate= nothing Thiopental= Dec BP/Respir |
