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50 Cards in this Set

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Alzheimers
AChase Inhib(bc ACh deficit)
Donepezil
Asthma
Methacholine
flush, sweat, cramp
Urinary Retention
Mathacholine
Pilocarpine
get miosis, cycloplegia
Dec IOP
via:Inc Outflow of AqHum
Nicotine
Induces CYP450
Inc HR/BP, Vasocnstrct,
Inc GI motility
Diag Myasthenia
Edophonium
and diffx myasthenic/cholinergic crisis
Treat Myasthenia
Neostigmine
always with atropine to prvnt indirect musc S/E
OP Poisoning
lacrimate, salivate, miosis, dyspnea
Tx: Atropine+Pralidoxime
Plant poison Inc ACh Stim
Trt with Atropine
Plant poison Dec ACh Stim
Trt with Physostigmine
Depol NM BLock
Non-competitive
Succinylcholine
fascic then flaccid
phaseII like competitive
Non-Depol NM Block
Competitive
Curare
MEP never depol
No fascic
Chng ACh-R density
Myasthenia: Dec
Burn: Inc
Denervate: Inc
Succinyl effect same dir
Curare effect opp dir
Direct Adrenergic Agonists
NE, Epi, DA
NE
Dec HR via Baroreflex
(this is blocked by Atropine)
DA
Maint dp/dt post MI
bc Inc RBF (other Dec it)
Epi
Epi+ a-blocker: only B effects (Inc HR, Dec BP)
Epi+ B-blocker: only a effects (Inc BP)
Add to Local Anesth keep local
Tyramine
C/I in MAOA/BI
Phenelzine, Tranylcypromine
ADD/ADHD
Methylphenidate
Amphetamine Toxicity
Toxic Psychosis:
Paranoid, Formication

Trt: Chlorpromazine
a-Blockers
Phentolamine, Prazosin, Phenoxybenzamine
Trt Migraine
Ergotamine, Dihydroergot.
Partial a-Agonists
S/E of a-Blocker
Orthostatic Hypotension
Tamsulosin
Block a1A-R in GU
For BPH to enhance voiding
Surgery for Pheochromocytoma
Pretreat w/a-Blocker and Non-selective B-Blocker
Prvnt Chng BP by Epi released
a knocks it dwn, B kicks it up
B-Blockers
Block B1:
Atenolol, Metoprolol
Block B1&B2:
Propranolol, Timolol
B-Blocker use
Angina
Dec HR
Dec O2 demand
timolol
Dec IOP w/o cycloplegia
(no propranolol bc anesthetic)
Reserpine
Dec NE release
No effect from TAP drugs:
Tyramine, Amphetamine
No a effects with Ephedrine
Cocaine
Block uptake NE, Epi, DA, 5-HT
Euphoria bc release DA in Nuc Accumbens
Local Anesth: block Na chnl
Toxic= Halo vision
MAOI
Inhib both A&B:
Phenelzine, Tranylcypromine
Inhib only B:
Selegiline (No DA brkdwn)
MAOI rxn
Cheese Reaction:
Inhib of MAOA in gut wall
lets tyramine in
Releases NE (HT/Tach)
Anti-HTN
Clonidine, a-MethylDopa
Stim a2-R: Dec NE/Renin Act
S/E= flu, +Coombs
Withdrawl Synd= Inc HR
A. Vasodilator
Hydralazine, Minoxidil, Diazoxide
Dec TPR/BP, Inc HR/CO
Give B-blocker w/it
Hydralazine S/E
SLE like:
Arthralgia, Fever, Malar Rash
HTN Emergency
Sodium Nitroprusside
Sodium Nitroprusside
Balanced Vasodilate
Bc release NO
Normotensive no CO chng
CHF inc CO
Ca2+ Blocker
Nifedipine (vessels)
Diltiazem
Verapamil (Hrt)
For Exertional/Vasospastic Angina
Dec dp/dt
B-blocker, Ca2+ blocker
ACE Inhib
Captopril, Enalapril
Prvnt Cnversion to ATII
Dec TPR/BP no Chg HR/CO
ACE Inhib S/E
Dry Cough
Bc reflex bc no brkdwn Bradykinin
Trt: d/c or Aspirin prvnt
Causitive Agent of ACEI Cough
PGD or Bradykinin
Losartan
ATII-R Antag (No ACEI cough)
Acetazolamide
Inhib CA to prvnt ReAbs Bicarb
Inhib prod AqHu, CSF, gastric acid
Trt Alt Sickness: Stim Respir
Make Urine Alkaline
CAI (Acetazo) or NaBicarb
Inc clrnce Acidic Drug
Make Urine Acidic
Ammonium Cl
Inc clrnce Basic Drug
Statin
Inhib HMG CoA Reductase
Inc Synth LDL-R
Take up LDL
Dec LDL/Tc (sm Inc HDL)
Ezetimibe
Inhib Chol Abs in GI
Inc LDL-R so take up LDL
Only LDL/Tc lower
Gemfibrozil/Fenofibrate
Act Lipoprot Lipase
Inc Hydrolysis of VLDL
Dec everything
Trt HyperTGemia
S/E= Rhabdo
Niacin
Inc HDL
S/E= Flush itch