Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
50 Cards in this Set
- Front
- Back
|
Alzheimers
|
AChase Inhib(bc ACh deficit)
Donepezil |
|
|
Asthma
|
Methacholine
flush, sweat, cramp |
|
|
Urinary Retention
|
Mathacholine
|
|
|
Pilocarpine
|
get miosis, cycloplegia
Dec IOP via:Inc Outflow of AqHum |
|
|
Nicotine
|
Induces CYP450
Inc HR/BP, Vasocnstrct, Inc GI motility |
|
|
Diag Myasthenia
|
Edophonium
and diffx myasthenic/cholinergic crisis |
|
|
Treat Myasthenia
|
Neostigmine
always with atropine to prvnt indirect musc S/E |
|
|
OP Poisoning
|
lacrimate, salivate, miosis, dyspnea
Tx: Atropine+Pralidoxime |
|
|
Plant poison Inc ACh Stim
|
Trt with Atropine
|
|
|
Plant poison Dec ACh Stim
|
Trt with Physostigmine
|
|
|
Depol NM BLock
|
Non-competitive
Succinylcholine fascic then flaccid phaseII like competitive |
|
|
Non-Depol NM Block
|
Competitive
Curare MEP never depol No fascic |
|
|
Chng ACh-R density
|
Myasthenia: Dec
Burn: Inc Denervate: Inc Succinyl effect same dir Curare effect opp dir |
|
|
Direct Adrenergic Agonists
|
NE, Epi, DA
|
|
|
NE
|
Dec HR via Baroreflex
(this is blocked by Atropine) |
|
|
DA
|
Maint dp/dt post MI
bc Inc RBF (other Dec it) |
|
|
Epi
|
Epi+ a-blocker: only B effects (Inc HR, Dec BP)
Epi+ B-blocker: only a effects (Inc BP) Add to Local Anesth keep local |
|
|
Tyramine
|
C/I in MAOA/BI
Phenelzine, Tranylcypromine |
|
|
ADD/ADHD
|
Methylphenidate
|
|
|
Amphetamine Toxicity
|
Toxic Psychosis:
Paranoid, Formication Trt: Chlorpromazine |
|
|
a-Blockers
|
Phentolamine, Prazosin, Phenoxybenzamine
|
|
|
Trt Migraine
|
Ergotamine, Dihydroergot.
Partial a-Agonists |
|
|
S/E of a-Blocker
|
Orthostatic Hypotension
|
|
|
Tamsulosin
|
Block a1A-R in GU
For BPH to enhance voiding |
|
|
Surgery for Pheochromocytoma
|
Pretreat w/a-Blocker and Non-selective B-Blocker
Prvnt Chng BP by Epi released a knocks it dwn, B kicks it up |
|
|
B-Blockers
|
Block B1:
Atenolol, Metoprolol Block B1&B2: Propranolol, Timolol |
|
|
B-Blocker use
|
Angina
Dec HR Dec O2 demand |
|
|
timolol
|
Dec IOP w/o cycloplegia
(no propranolol bc anesthetic) |
|
|
Reserpine
|
Dec NE release
No effect from TAP drugs: Tyramine, Amphetamine No a effects with Ephedrine |
|
|
Cocaine
|
Block uptake NE, Epi, DA, 5-HT
Euphoria bc release DA in Nuc Accumbens Local Anesth: block Na chnl Toxic= Halo vision |
|
|
MAOI
|
Inhib both A&B:
Phenelzine, Tranylcypromine Inhib only B: Selegiline (No DA brkdwn) |
|
|
MAOI rxn
|
Cheese Reaction:
Inhib of MAOA in gut wall lets tyramine in Releases NE (HT/Tach) |
|
|
Anti-HTN
|
Clonidine, a-MethylDopa
Stim a2-R: Dec NE/Renin Act S/E= flu, +Coombs Withdrawl Synd= Inc HR |
|
|
A. Vasodilator
|
Hydralazine, Minoxidil, Diazoxide
Dec TPR/BP, Inc HR/CO Give B-blocker w/it |
|
|
Hydralazine S/E
|
SLE like:
Arthralgia, Fever, Malar Rash |
|
|
HTN Emergency
|
Sodium Nitroprusside
|
|
|
Sodium Nitroprusside
|
Balanced Vasodilate
Bc release NO Normotensive no CO chng CHF inc CO |
|
|
Ca2+ Blocker
|
Nifedipine (vessels)
Diltiazem Verapamil (Hrt) For Exertional/Vasospastic Angina |
|
|
Dec dp/dt
|
B-blocker, Ca2+ blocker
|
|
|
ACE Inhib
|
Captopril, Enalapril
Prvnt Cnversion to ATII Dec TPR/BP no Chg HR/CO |
|
|
ACE Inhib S/E
|
Dry Cough
Bc reflex bc no brkdwn Bradykinin Trt: d/c or Aspirin prvnt |
|
|
Causitive Agent of ACEI Cough
|
PGD or Bradykinin
|
|
|
Losartan
|
ATII-R Antag (No ACEI cough)
|
|
|
Acetazolamide
|
Inhib CA to prvnt ReAbs Bicarb
Inhib prod AqHu, CSF, gastric acid Trt Alt Sickness: Stim Respir |
|
|
Make Urine Alkaline
|
CAI (Acetazo) or NaBicarb
Inc clrnce Acidic Drug |
|
|
Make Urine Acidic
|
Ammonium Cl
Inc clrnce Basic Drug |
|
|
Statin
|
Inhib HMG CoA Reductase
Inc Synth LDL-R Take up LDL Dec LDL/Tc (sm Inc HDL) |
|
|
Ezetimibe
|
Inhib Chol Abs in GI
Inc LDL-R so take up LDL Only LDL/Tc lower |
|
|
Gemfibrozil/Fenofibrate
|
Act Lipoprot Lipase
Inc Hydrolysis of VLDL Dec everything Trt HyperTGemia S/E= Rhabdo |
|
|
Niacin
|
Inc HDL
S/E= Flush itch |
