Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
7 Cards in this Set
- Front
- Back
|
Levodopa
|
Increases DA production and release by surviving dopaminergic neurons
Useful in the early stages of the disease |
|
|
Side Effects of Levodopa
|
Nausea
Psychosis Depression Irregular involuntary movements Hypotension |
|
|
Carbidopa
|
Used in conjunction with Levodopa
Blocks levodopa conversion to dopamine and NE in peripheral neurons Blocks side effects in periphery Increases central bioavailability |
|
|
Amantadine
|
Causes release of dopamine from dopamineric neurons
Slows reuptake of dopamine Useful in early stages of disease |
|
|
Selegiline
|
Inhibits activity of brain monoamine oxidase to inhibit degradation of DA
Increase brain dopamine bioavalability w/in synaptic gap Useful in early stages of disease |
|
|
Bromocriptine
Pergolide Ropinirole |
Dopamine receptor agonists
Do not alter dopamine synthesis or degradation Also used in restless leg syndrome Useful in later stages of disease |
|
|
Trihexyphenidyl
Benztropine Biperiden |
Antimuscarinic Drugs
Atropine-like in action Not dependent on DA neuron survival Useful in all stages of disease |
