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10 Cards in this Set
- Front
- Back
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Define Parkinsonism
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Group of disorders that have impaired motor activity -bradykinesia and instability
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Two categories of Parkinsonism
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Primary - Parkinson's
Secondary |
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Causes of Primary Parkinsonism
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Familial
Idiopathic (most common 90%) Other Neurodegenerative disorders with pathologies associated with a-synuclein, primary tau, & primary amyloid Genetically mediated disorders with occasional parkinsonian features including Wilson's & Huntington's Miscellanenous - Vascular, normal pressure hydrocephalus, catatonia, cerebral palsy |
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Causes of Secondary Parkinsonism
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Repeated head trauma
Infectious and post infectious disease including neurosyphillis Metabolic conditions including hypoparathyroidism, non-wilson hepatolenticular degeneration Drugs Toxins |
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What drugs can cause secondary parkinsonism?
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Neuroleptics
Antipsychotics Anti-emetics Dopamine depleting agents - reserpine, tetrabenazine Methyldopa Lithium Carbonate Valporic Acid Fluxetine |
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What toxins can cause secondary parkinsonism?
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MTPT
Manganese Cyanide Methanol Cabrbon monoxide Carbon disulfide N-hexane |
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What is the mean age of onset of parkinson's disease?
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58 to 62
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What is the progression of parkinson's disease?
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Chronic progressive disorder over the span of 10 to 20 years
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Name the four primary symptoms of parkinson's?
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TRAP
Tremor (hands, arms, legs, jaw, face) unilateral or bilateral Rigidity or stiffmess Akinesia or bradykinesia Postural Instability |
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What is the most recognized characteristic of Parkinson's and describe it?
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Tremor - 3 to 6 beats per minute back and forth motion of hand, worsens at rest and with stress
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