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27 Cards in this Set
- Front
- Back
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clinical manifestations of Parkinson's
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tremor at rest
bradykinesia flat affect festinating gait |
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frequency in general population
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1-2 per 1000 people
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frequency in >85 years of age
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50%
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drug that doesn't cross blood-brain barrier
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Dopamine
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combo drug of L-Dopa and carbidopa
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Sinemet
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List Dopamine agonists
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Bromocriptine
Pergolide |
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1st line drug for Parkinsons
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Bromocriptine
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administration of bromocriptine
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oral
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metabolizes serotonin/norepinephrine
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MAO-A
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metabolizes dopamine
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MAO-B
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selective monoamine oxidase B inhibitor
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Selegiline
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adjunctive treatment to L-DOPA
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Selegiline or Carbidope
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antiviral drug for Parkinsons
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Amantadine
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contraindications of selegiline/MAO
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tricyclic antidepressants
serotonin specific reuptake inhibitors (SSRI) |
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self-mutilating syndrome caused by
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too much serotonin
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List Anticholernergics for Parkinsons
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Benztropine
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contraindications for anticholinergics
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prostatic hyperplasia
obstructive GI disease |
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Tardive Dyskinesia
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consequence of long-term antipsychotic drug treatment
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list anticholinergics for Parkinsons
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Benztropine
Cogentin biperiden orphenadrine procyclidine |
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List MAOI for Parkinson's
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Selegiline
Tolcapone |
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Inhibits COMT for Parkinsons
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tolcapone
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drug used early in Parkinsons while system still exists
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Selegiline
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types of SSRI
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Prozac
Zoloft Paxil |
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improves rigitdity and tremor, but minor effect on bradykinesia
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Anticholinergics
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experience decline in response in 3-5 years
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L-dopa and carbidopa
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adverse effects of bromocriptine
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hallucinatiosn
confusion nausea hypotension |
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Contraindications for antimuscarinics for Parkinsons'
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prostatic hyperplasia
obstructive GI disease |
