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20 Cards in this Set
- Front
- Back
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What are the MAO-B inhibitors?
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Selegiline and Rasagiline
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What is the MOA for MAO-B inhibitor?
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MAO-B inhibitors bind to the MAO-B receptors irreversibly blocking the binding of dopamine.
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This drug is an antiviral that is used to treat mild Parkinson's symptoms and especially tremor.
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Amantadine
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Name four anticholinergic drugs used in the treatment of Parkinson's.
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Benztropine, Trihexyphenidyl, Procyclidine, Biperidine, Diphenhydramine
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What is the most commonly used anticholinergic used for the treatment of Parkinson's?
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Benztropine (Cogentin)
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What are the ergoline agonists currently being used?
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Bromocriptine and Pergolide
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What are the none-ergoline agonists currently being used?
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Ropinirole, Pramipexole, Apomorphine, and Rotigotine
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What is the MOA of the dopamine agonists?
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Dopamine agonists enhance dopaminergic transmission by binding to post-synaptic dopamine receptors.
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T/F Dopamine agonists increase dopamine concentrations.
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False
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What is the apomorphine primarily used for?
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Apomorphine (Apokyn) is used for the acute treatment of severe rigidity or inability to move (rescue therapy).
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What drug is most often given with apomorphine as an antiemetic?
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trimethobenzamide
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Why is it important that Levodopa cross the BBB before being metabolized to dopamine?
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Dopamine cannot cross the BBB.
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What is the MOA of tolcapone and entacapone?
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They inhibit COMT so it cant metabolize levadopa.
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T/F Levodopa slows the course of Parkinson's?
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False
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What is the gold standard drug for the treatment of Parkinson's?
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Levodopa
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What is the MOA of carbidopa and why is it useful?
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Carbidopa is an AADC inhibitor so levodopa is not brokendown in the perifery and can get to the CNS.
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what is the rule of thirds in regaurds to levodopa?
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1/3 of patients respond well, 1/3 of pts. less well, 1/3 of pts. can't tolerate or dont respond.
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How long can a Parkinson's pt. usually be on levodopa before there is a decrease in their responce to the medication?
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3 - 4 years
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What symptom of Parkinson's is most relieved by levodopa?
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Bradykinesia
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What antipsycotics are often used on Parkinson's pts.?
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Clozapine, Olanzapine, Quetiapine
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