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29 Cards in this Set

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  • Back
What is the MOA of antidepressants?
Increase the actions of monoamine neurotransmitters, particularly serotonin, and/or norepinephrine activity in the brain by altering the metabolism, decreasing the reuptake, and/or through receptor antagonism.
What is the main MOA of TCAs, SSRIs, and NRIs ?
All block the reuptake of serotonin and/oe norepi into the presynaptic nerve terminal
What is the MOA of MAO inhibitors?
Block the major metabolic pathways for the monoamine neurotransmitters (serotonin, norepi, dopamine) which cause an increased accumulation of neurotransmitter in presynaptic storage sites throughout the cns and pns.
How do alpha-2 and 5H receptors react to antidepressants?
Immediate increase of neurotransmiter --> alpha-2 and 5-HT response causes a DECREASE in neurotransmitter release --> down regulation of presynaptic autoreceptors (alpha-2 and 5-HT) -> increased Neurotransmitter levels --> down regulation of of POST SYNAPTIC receptors (b1 adrenergic or serotonin)
Which TCA are mixed NE and serotonin reuptake inhibitors?
Amitriptyline and Imiramine
Which TCA is selective serotonin reuptake inhibitor?
Clomipramine
Which TCA is used in adjunct to tx COPD and sleep-apnea?
Protripryline
WHich TCA is a selective NE reuptake inhibitos ?
Desipriamine
Which TCa has no effect of amine neurotransmitter reuptake ?
Trimipramine
What is the only FDA approved use for the NRI Atomoxetine?
ADHD
What causes Serotonin Syndrome?
SSRI + MAOI = hyperthermia, muscle rigidity, myoclonus..
What is the only FDA approved use for the NRI Atomoxetine?
ADHD
What causes Serotonin Syndrome?
SSRI + MAOI = hyperthermia, muscle rigidity, myoclonus..
What drugs are MAO inhibitors that have serious SE including hypertensive crisis?
-Phenelzine (Nardil)
-Trancypromine (Parnate)
-Moclobemide (manerix, canada)
What is the MOA of SSRI and NRI?
Desensitization of post synaptic receptors.
What is the black box warning for children/teens taking antidepressants?
Increased suicide risk
Which TCA is used commonly for neuropathic pain?
Amitriptyline
Which TCA is a STIMULANT that is used as adjunctive tx for pts with COPD and sleep apnea?
Protriptyline (Vivactil)
Which TCA is a potent NE reuptake inhibitor?
Desipriamine (NORpramine)
Which TCA is highly sedative, used topically for eczema, migrane prophylaxis, and alcoholism?
Doxepin ( Sinequan, Adapin)
What antidepressant is CI with thioridazine because it causes an increate in QT prolongation?
Prozac
What is the only SSRI approved for pediatic use?
Prozac
Which MAO Inhibitor is irreversible and which is reversible?
Irreversible - Phenelzine

Reversible - Trancypromine (Parnate)
What is the treatment for a hypertensive crisis?
Phentolamine (alpha-adrenergic blocker)
What are contraindications for MAOIs?
- amphetamines, cocaine, LA with EPI!, foods with a lot of Tyramine, OTC meds.
What Heterocyclic antidepressant is is used for smoking cessation but can cause a high incidence of seizues?
Buproprion
Why is Lithium not used for ACUTE mania?
because it has a delayed onset of 7-10 days
What can cause Lithium toxicities?
-Anything causing a decrease in serum Na which can lead to increase Li and toxicity. - sweating, decreased renal function, diarrhea..

-NSAIDS
What other drugs other than Lithium could used to tx someone with bipolar disorder?
-Valproate (Depakene)
- Carbamazepine
-Olanzapine (Zyprexa)