Parker Pharm Ii: Packet 5- Antidepressants

Front 1

What is the MOA of antidepressants?

Back 1

Increase the actions of monoamine neurotransmitters, particularly serotonin, and/or norepinephrine activity in the brain by altering the metabolism, decreasing the reuptake, and/or through receptor antagonism.

Front 2

What is the main MOA of TCAs, SSRIs, and NRIs ?

Back 2

All block the reuptake of serotonin and/oe norepi into the presynaptic nerve terminal

Front 3

What is the MOA of MAO inhibitors?

Back 3

Block the major metabolic pathways for the monoamine neurotransmitters (serotonin, norepi, dopamine) which cause an increased accumulation of neurotransmitter in presynaptic storage sites throughout the cns and pns.

Front 4

How do alpha-2 and 5H receptors react to antidepressants?

Back 4

Immediate increase of neurotransmiter --> alpha-2 and 5-HT response causes a DECREASE in neurotransmitter release --> down regulation of presynaptic autoreceptors (alpha-2 and 5-HT) -> increased Neurotransmitter levels --> down regulation of of POST SYNAPTIC receptors (b1 adrenergic or serotonin)

Front 5

Which TCA are mixed NE and serotonin reuptake inhibitors?

Back 5

Amitriptyline and Imiramine

Front 6

Which TCA is selective serotonin reuptake inhibitor?

Back 6

Clomipramine

Front 7

Which TCA is used in adjunct to tx COPD and sleep-apnea?

Back 7

Protripryline

Front 8

WHich TCA is a selective NE reuptake inhibitos ?

Back 8

Desipriamine

Front 9

Which TCa has no effect of amine neurotransmitter reuptake ?

Back 9

Trimipramine

Front 10

What is the only FDA approved use for the NRI Atomoxetine?

Back 10

ADHD

Front 11

What causes Serotonin Syndrome?

Back 11

SSRI + MAOI = hyperthermia, muscle rigidity, myoclonus..

Front 12

What is the only FDA approved use for the NRI Atomoxetine?

Back 12

ADHD

Front 13

What causes Serotonin Syndrome?

Back 13

SSRI + MAOI = hyperthermia, muscle rigidity, myoclonus..

Front 14

What drugs are MAO inhibitors that have serious SE including hypertensive crisis?

Back 14

-Phenelzine (Nardil)
-Trancypromine (Parnate)
-Moclobemide (manerix, canada)

Front 15

What is the MOA of SSRI and NRI?

Back 15

Desensitization of post synaptic receptors.

Front 16

What is the black box warning for children/teens taking antidepressants?

Back 16

Increased suicide risk

Front 17

Which TCA is used commonly for neuropathic pain?

Back 17

Amitriptyline

Front 18

Which TCA is a STIMULANT that is used as adjunctive tx for pts with COPD and sleep apnea?

Back 18

Protriptyline (Vivactil)

Front 19

Which TCA is a potent NE reuptake inhibitor?

Back 19

Desipriamine (NORpramine)

Front 20

Which TCA is highly sedative, used topically for eczema, migrane prophylaxis, and alcoholism?

Back 20

Doxepin ( Sinequan, Adapin)

Front 21

What antidepressant is CI with thioridazine because it causes an increate in QT prolongation?

Back 21

Prozac

Front 22

What is the only SSRI approved for pediatic use?

Back 22

Prozac

Front 23

Which MAO Inhibitor is irreversible and which is reversible?

Back 23

Irreversible - Phenelzine

Reversible - Trancypromine (Parnate)

Front 24

What is the treatment for a hypertensive crisis?

Back 24

Phentolamine (alpha-adrenergic blocker)

Front 25

What are contraindications for MAOIs?

Back 25

- amphetamines, cocaine, LA with EPI!, foods with a lot of Tyramine, OTC meds.

Front 26

What Heterocyclic antidepressant is is used for smoking cessation but can cause a high incidence of seizues?

Back 26

Buproprion

Front 27

Why is Lithium not used for ACUTE mania?

Back 27

because it has a delayed onset of 7-10 days

Front 28

What can cause Lithium toxicities?

Back 28

-Anything causing a decrease in serum Na which can lead to increase Li and toxicity. - sweating, decreased renal function, diarrhea..

-NSAIDS

Front 29

What other drugs other than Lithium could used to tx someone with bipolar disorder?

Back 29

-Valproate (Depakene)
- Carbamazepine
-Olanzapine (Zyprexa)