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25 Cards in this Set
- Front
- Back
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Characteristics of Paramyxoviridae
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Negative sense single strand RNA
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Shape
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Helical, enveloped, transcriptase in virion
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Proteins
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Fo: Fusion glycoprotein
HN: glycoprotein M: matrix SH: not important RNA Proteins: L,N, P |
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Describe attachment
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receptor
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Describe fusion
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fusion with plasma membrane, does not require low pH
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Describe replication
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nucleic acid released into cytoplasm, all replication in cytoplasm and budding at plasma membrane
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What type of mRNA does it have
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genomic and antigenomic transcription mRNA
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Describe the synthesis
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viral polymerase transcribes genome template to yield mRNAs.
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When doe sit shift to full (-) RNA
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When concentration of N protein increases
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Describe genome transcription
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Conserved transcription regulatory sequences, E end, I intergenic, S start.
Each gene transcribed 30% less than next |
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What are the diseases from Paramyxo
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Mumps, Measles, Distemper, Respiratory syncytial , human para influenza, Nipah
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Mumps
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Salivary glands swollen
Human only, person-to-person 3 week incubation starts local then systemic |
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Mumps encephalitis
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high neuroinvasive, not neurovirulent
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Risk
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link with insulin dependent diabetes
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Adult infection
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can lead to sterility, abortion
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Treatment
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single dose is not sufficient for immunity, needs second shot
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Measles
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Fever, cough, conjuctivitis
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Spread
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during conjunctivitis phase
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Complications from Measles
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bacterial pneumonia
1:20 develop pneumonia 1:1000 encephalitis Case fatality in malnutrition countries is 25% Blindness |
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Risk factor
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illness at young age, native Americans 15 Million died during conquista
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Distemper
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fever, loss of appetite, neurological issues for survivors
"Chewing gum" More on puppies, good recovery Vaccine |
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Other diseases
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Croup
Bronchiolitis Pneumonia Syncytium |
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Measles complications (2)
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Acute disseminated encephalomyelitis
Measles inclusion body encephalitis Subacute sclerosing panencephalitis |
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When does each complication on measles happen?
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ADEM 8 days to 1 month
MIBE 1 month to 9 months SSPE 3 years to 12 years |
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Vaccine
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Measles-Mumps-Rubella MMR
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