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21 Cards in this Set
- Front
- Back
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What is the lifecycle of paramyxo? |
1. Entry into cell by membrane fusion or endocytosis 2. Nucleocapisid uncoats 3. Viral RNA polymerase copies - RNA into +mRNA 4. Protein synthesis (-) genome replicates 5. virus replication and budding |
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Paramyxo virus |
- helical ssRNA
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Parainfluenza virus key points |
* 4 types *40% of cases come from type 1 * 2-7 day incubation * replicated in ciliated epithelial cells *reinfection is common but may be mild or asymptomatic
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LRI from parainfluenza virus is the most common cause of |
croup |
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What is the most common cause of hospitalization in children? |
parainfluenza virus |
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How is parainfluenza virus spread? |
*aerosol/fomites *cough sneeze followed by touching mucous membranes |
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How do you prevent parainfluenza? |
wash hands avoid contact with infected individuals don't touch mucous membranes |
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RSV main points |
*2 strains *A and B * a more severe |
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What is the leading cause of viral bronchitis in infants? |
RSV |
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What is RSV more likely to cause? |
LRI |
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What is commonly coinfecting with RSV |
Human metapneumo virus |
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Human metapneumovirus key facts |
*almost all children seropositive by 5 * seronegative children, immunocompromised, elderly at risk |
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Hendra virus |
austrailia--> bats--> horses--> humans neuro flu--> encephalitis |
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Nipah virus |
malaysia--> bats--> pigs--> humans flu--> encephalitis 100 dead 300 infected |
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PIV1 seasonal trend |
fall every other year |
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PIV2 seasonal trend |
fall every year |
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PIV3 |
prolonged seasonal occurance spring/summer |
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PIV4 |
rare and erratic |
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2-3 Serotype |
lower rep- avian |
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2-6 serotype |
upper resp- general |
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seasonal fro RSV |
late fall early spring annually |
