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21 Cards in this Set
- Front
- Back
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pink plaque w/ silvery scales
elbows, knees, scalp, lumbar NAIL CHANGES (e.g. pitting) assoc w/ arthritis, myopathy, enteropathy, spondylitic jt ds or AIDS |
psoriasis
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what are the 3 forms of pustular psoriasis?
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pustules on typical plaques
pustules on palms/ soles generalized eruption, fever, leukocytosis |
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what is a serious complication of psoriasis?
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erythroderma: total body erythema & scaling, leading to fluid & protein loss & hospitalization
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what is the koebner phenomenon?
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trauma precipitating psoriatic lesion
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what is guttate psoriasis?
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generalized eruption of small lesions AFTER strep pharyngitis
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what is the pathogenesis of psoriasis?
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Th1 cytokines, GF's lead to keratinocyte proliferation, transit time goes from 28 days to 3-4
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acanthosis
mitotic figures above cell layer extensive parakeratotic scale thin s. granulosum munro microabscesses (neutrophils in s. corneum) elongated rete ridges Auspitz sign dermal inflammation |
psoriasis
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what is Auspitz sign?
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pulling off scale causes multiple minute bleeds because vessels in papillae are close to parakeratotic scale at surface
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bright red
smooth folds of skin |
reverse psoriasis
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what is the DDx of psoriasis?
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fungal infections (nails)
seborrhic dermatitis (scalp) pityriasis rosea |
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what improves psoriasis?
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sunlight
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what is the Tx for psoriasis?
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steroids (intermittently),
topical tars & anthralin, vit D derivative, tazarotene (category X) UV light MTX, psoralen, retinoid, cyclosporine |
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chronic inflammation in sebaceous gland area
lipophilic skin yeast P. ovale infants & postpubertal assoc w/ AIDS, parkinson's |
seborrheic dermatitis
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bilateral, symmetrical rash
scalp, eyebrows, axilla, groin, etc patches/ plaques distinct margins greasy scaling |
seborrheic dermatitis
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early spongiosis
later acanthosis w/ parakeratosis follicular lipping (neutrophils, serum at ostia of follicle) |
seborrheic dermatitis
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herald patch (2-5cm tan-pink round lesion w/ delicate scale, days/wks before general rash)
christmas tree pattern of lesions on trunk |
pityriasis rosea
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mounds of parakeratosis
spongiosis superficial perivascular infiltrate extravasated RBC's |
pityriasis rosea
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what is important to include in the DDx of pityriais rosea?
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secondary syphillis
*no herald patch, palms/soles, systemically ill |
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pruritic
purple polygonal planar papules (w/ Wickam's striae = white dots/lines) plaques oral lesion w/ white reticular appearance |
lichen planus
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what drugs can cause lichen planus eruption?
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thiazides
phenothizines gold quinidine quinacrine chloroquine |
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**interface dermatitis (lymph infiltrate at DEJ)
basal cell necrosis sawtooth DEJ civatte or colloid bodies in basal layer & dermis** |
lichen planus (can last 1-2yrs)
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