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11 Cards in this Set

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structural properties of papillomavirus?
icos, small and nonenveloped, ds circular DNA genome, promote cell growth (oncogenic)
important proteins in HPV 16 (oncovirus)?
E is early, L is late. E1 (helicase that is the only viral protein needed for replication), E2 helps E1 and is a transactivator, E5, 6, and 7 are oncoproteins. L1 and L2 are capsid proteins
overview of general lifecycle and role of E6 and E7?
replicates in basal epi in skin/mucosa, migrates towards the surface where capsid proteins are expressed and more replication occurs…. E6 binds p53 to suppress apoptosis bc ssDNA is being made for virus not ds. E7 binds tumor suppressors
types of HPV pathology?
warts which are benign outgrowths of cells, and cancer from cell transformation, note there are over 200 different viruses and each has a predilection for where they like to infect.
transmission of HPV?
direct contact through breaks in skin, sex (most common STD), infants at delivery, fomites
what is the fate of over 90% of lesions?
spontaneous regression
clinical syndromes and species?
cutaneous (1 to 4), laryngeal (6 and 11), condyloma acuminatum (6 and 11), cervical neoplasia (species 7,9: HPV 16 (50%), HPV 18 (20%), 31, 33, etc)
high irisk HPV types?
cervical carcinoma in HPV 16, 18, 31, 33, etc; vaginal, penile and anal in HPV 16 and 18; adenocarcinoma in 18, 39, 45; esophagus HPV 16; head and neck in 16; note over 7% of cancers in women worldwide
risks for cervical cancer?
infection with high risk HPV types, persistent infection, smoking, compromised immune system
HPV diagnosis?
microscopically for hyperkeratosis; papanicolaou smear for koilocytosis (cytoplasmic vacuolization), PCR and molecular probes for virus typing, and colposcopy… (?)
HPV treatment and control?
removal, local immune stimulation for genital warts, avoid direct contact (use a condom), vaccine (16, 18 - 6,11)